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S009

Sigma-Aldrich

LY-165,163

solid

Synonym(s):

4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine, p-Aminophenethyl-m-trifluoromethylphenyl piperazine, PAPP

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About This Item

Empirical Formula (Hill Notation):
C19H22F3N3
CAS Number:
1814-64-8
Molecular Weight:
349.39
MDL number:
MFCD00055098
UNSPSC Code:
12352202
PubChem Substance ID:
24278123
NACRES:
NA.77

form

solid

Quality Level

100

color

off-white

solubility

0.1 M HCl: slightly soluble
H2O: insoluble
ethanol: freely soluble

SMILES string

Nc1ccc(CCN2CCN(CC2)c3cccc(c3)C(F)(F)F)cc1

InChI

1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

InChI key

GAAKALASJNGQKD-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350) , HTR1D(3352)

Biochem/physiol Actions

Selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 269(1), 121-131 (1994-04-01)
In view of the involvement of central alpha 1-adrenoceptors in the expression of 5-HT1A receptor-mediated spontaneous tail-flicks (STFs) in the rat, this study examined whether the putative alpha 1-adrenoceptor antagonist (alpha 1-antagonist) properties of certain 5-HT1A receptor agonists, (+)-flesinoxan and
H C Jackson et al.
Neuropharmacology, 28(6), 635-642 (1989-06-01)
The effects of a variety of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on behaviour in 5- and 20-day old rat pups have been investigated. Increased locomotion and head-weaving responses were induced in both age groups by 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin; 5-HT1A agonist);
M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 273(3), 1418-1427 (1995-06-01)
In this study, we examined the influence of the actions of the halogenated phenylpiperazine LY 165,163 at dopamine D1, D2 and D3 receptors on its 5-HT1A agonist properties in vivo. LY 165,163 displayed marked affinity at striatal rat (r)D2 (pKi
T P Donohoe et al.
Psychopharmacology, 93(1), 82-86 (1987-01-01)
The putative serotonin (5-HT)1A agonist 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluormethylphenyl) piperazine (LY165163, PAPP) induces hyperphagia and hypothermia in rats, but unlike other 5-HT agonists, does not induce 5-HT stereotypy even at high doses (10 mg/kg sc). LY165163 (1 mg/kg) increased striatal DOPA accumulation in
W Hunter White et al.
Veterinary parasitology, 146(1-2), 58-65 (2007-03-27)
The neurotransmitter serotonin (5-hydroxy tryptamine or 5HT) regulates key physiological processes in nematodes such as locomotion and feeding. PAPP (p-amino-phenethyl-m-trifluoromethylphenyl piperazine) is a known agonist of the 5-HT(1Hc) receptor of the barber pole worm, Haemonchus contortus. In this study, PAPP
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