RES1052B-B7
BIOTIN
Synonym(s):
Biotin, D-Biotin, Bios II, Coenzyme R, Vitamin B7, Vitamin H
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About This Item
Empirical Formula (Hill Notation):
C10H16N2O3S
CAS Number:
Molecular Weight:
244.31
EC Number:
200-399-3
UNSPSC Code:
12352201
NACRES:
NA.21
Beilstein/REAXYS Number:
86838
MDL number:
InChI key
YBJHBAHKTGYVGT-ZKWXMUAHSA-N
InChI
1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
SMILES string
[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2
biological source
synthetic
assay
97.5-100.5%
form
powder
impurities
Trace metals; tested
color
white
mp
231-233 °C (lit.)
suitability
suitable for manufacturing use
Quality Level
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General description
Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.
M-Clarity Program
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
M-Clarity Program
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.
Packaging
Product is available in the following package sizes:
RES1052B-B701X: 1 g container
RES1052B-B707X: 10 g container
RES1052B-B708X: 25 g container
RES1052B-B701X: 1 g container
RES1052B-B707X: 10 g container
RES1052B-B708X: 25 g container
Legal Information
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Carmen Smarandache-Wellmann et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(16), 5627-5639 (2014-04-18)
We describe synaptic connections through which information essential for encoding efference copies reaches two coordinating neurons in each of the microcircuits that controls limbs on abdominal segments of the crayfish, Pacifastacus leniusculus. In each microcircuit, these coordinating neurons fire bursts
Majid Alfadhel et al.
Orphanet journal of rare diseases, 8, 83-83 (2013-06-08)
Biotin-responsive basal ganglia disease (BBGD) is an autosomal recessive neurometabolic disorder. It is characterized by sub acute encephalopathy with confusion, seizure, dysarthria and dystonia following a history of febrile illness. If left untreated with biotin, the disease can progress to
John E Cronan et al.
Current opinion in chemical biology, 15(3), 407-413 (2011-03-26)
Biotin synthesis requires the C7 α,ω-dicarboxylic acid, pimelic acid. Although pimelic acid was known to be primarily synthesized by a head to tail incorporation of acetate units, the synthetic mechanism was unknown. It has recently been demonstrated that in most
Stéphane Mann et al.
Biochimica et biophysica acta, 1814(11), 1459-1466 (2010-12-25)
The four last steps of biotin biosynthesis, starting from pimeloyl-CoA, are conserved among all the biotin-producing microorganisms. Two enzymes of this pathway, the 8-amino-7-oxononanoate synthase (AONS) and the 7,8-diaminopelargonic acid aminotransferase (DAPA AT) are dependent on pyridoxal-5'-phosphate (PLP). This review
Janos Zempleni et al.
Mutation research, 733(1-2), 58-60 (2011-08-30)
Biotin serves as a covalently bound coenzyme in five human carboxylases; biotin is also attached to histones H2A, H3, and H4, although the abundance of biotinylated histones is low. Biotinylation of both carboxylases and histones is catalyzed by holocarboxylase synthetase.
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