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Safety Information

RAB1046

Sigma-Aldrich

Human FGF-21 ELISA Kit

for cell culture supernatants, plasma, and serum samples

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum sample(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/ml

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FGF21(26291)

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Fibroblast growth factor 21 (FGF-21) plays a vital role in the regulation of glucose uptake in mouse 3T3-L1 and primary human adipocytes. In addition, it is also implicated in lipid metabolism and in energy balance. FGF-21 plays a key role in controlling oxidative stress cell response. Overexpression of the gene has been associated with the development of acute pancreatitis, obesity, insulin resistance and metabolic syndrome. Additionally, elevated expression of FGF-21 has been observed in patients with insulin resistance and type 2 diabetes mellitus (T2DM). Thus, it can be considered as a potent target for an effective treatment of diabetes.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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FGF-21 as a novel metabolic regulator
Kharitonenkov A, et al.
The Journal of Clinical Investigation, 1627-35 null
Fibroblast growth factor 21 and its novel association with oxidative stress.
Gomez-Samano M A, et al.
Redox Biology, 335-341 null
Circulating FGF-21 Levels in Normal Subjects and in Newly Diagnose Patients with Type 2 Diabetes Mellitus
Chen WW, et al.
Experimental and Clinical Endocrinology & Diabetes, 65-8 null

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