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species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2.5 pg/mL
standard curve range: 2.44-10000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... APOC3(345)
General description
The antibody pair provided in this kit recognizes Human Apolipoprotein C3.
ApoC-III is a glycoprotein that has 79 amino acids. It is coded by APOC3 gene. APOC3 is expressed in the liver and intestine. This gene is located on human chromosome 11.
ApoC-III is a glycoprotein that has 79 amino acids. It is coded by APOC3 gene. APOC3 is expressed in the liver and intestine. This gene is located on human chromosome 11.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Apolipoprotein C-III (APOC3) has the ability to prevent lipoprotein lipase (LPL) and hepatic lipase activity. It is considered as a major modulator of triglyceride metabolism.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
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Targeting APOC3 in the familial chylomicronemia syndrome.
Gaudet D, et al.
The New England Journal of Medicine, 371(23), 2200-2206 (2014)
Keishi Hata et al.
Biomedical research (Tokyo, Japan), 41(1), 33-42 (2020-02-25)
We investigated lipid metabolism in PXB-cells, which are human primary hepatocytes isolated from liver-humanized mice, and HepG2 and HuH-7 human hepatoma cell lines. Lipoprotein levels were higher in PXB-cells than in the 2 other cell lines, and PXB-cells mainly released
Apolipoprotein CIII Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study.
van Capelleveen JC, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 37(6), 1206-1212 (2017)
Li Li et al.
International journal of molecular medicine, 45(5), 1409-1416 (2020-04-24)
The aim of the present study was to identify potential serum biomarkers for insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) by comparing the differences in serum protein expression levels between PCOS patients with and without IR. PCOS
Åsa Sandin et al.
Scandinavian journal of clinical and laboratory investigation, 80(3), 230-235 (2020-02-29)
Apolipoprotein CIII (apoCIII) is associated with triglyceride (TG)-rich particles like VLDL and exerts an inhibitory effect of lipoprotein lipase. Increased levels are related to cardiovascular diseases and diabetes and therefore apoCIII has been proposed as a useful biomarker. Even if
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