RAB0235
Human IGFBP-3 ELISA Kit
for serum, plasma, cell culture supernatant and urine
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About This Item
NACRES:
NA.32
UNSPSC Code:
41116158
Gene information:
human ... IGFBP3(3486)
Input:
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
sample type serum
sample type cell culture supernatant(s)
sample type urine
Species reactivity:
human
Storage temp.:
−20°C
Shipped in:
wet ice
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable, capture ELISA: suitable
input
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 74.07-18000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IGFBP3(3486)
General description
The Human IGFBP-3 ELISA (Enzyme-Linked mmunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human IGFBP-3 in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Human IGFBP3
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Insulin-like growth factor-binding protein 3 (IGFBP3) is implicated in cell survival. In addition, it also facilitates cell death and tumorigenesis. Epigenetic changes in IGFBP3 affect non-small-cell lung cancer, hepatocellular carcinoma, ovarian cancer, skin cancer, urological cancers, breast cancer and gastric cancer. IGFBP3 is a primary growth inhibitor and can reverse the mitogenic functions of IGF-1 (insulin like growth factor 1) by inducing apoptosis.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Description
SDS
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
Regulatory Information
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Insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTOR pathway in prostate cancer.
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Song G, et al.
World Journal of Surgical Oncology, 14(1), 307-307 (2016)
Yan Wang et al.
Medical oncology (Northwood, London, England), 31(5), 921-921 (2014-03-29)
Growth factors in the brain are important to depression. We investigated the relationship between serum insulin-like growth factor (IGF-1) and IGF-binding protein-3 (IGFBP-3) concentration and risk of depression and the effect of psychological intervention on outcomes of high-grade glioma patients
Evaluation of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Expression Levels in Patients with Chronic Lymphocytic Leukemia.
Ayer M, et al.
Turkish journal of haematology : official journal of Turkish Society of Haematology, 33(4), 335-335 (2016)
Francesca D'Addio et al.
Nature communications, 13(1), 684-684 (2022-02-05)
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