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Safety Information

RAB0209

Sigma-Aldrich

Gastric Inhibitory Peptide EIA Kit

for serum, plasma, culture supernatant and cell lysates

Synonym(s):

GIP, Gastric inhibitory polypeptide , Glucose-dependent insulinotropic polypeptide, Incretin hormone

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

species reactivity

mouse, rat, human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
enzyme immunoassay: suitable

input

sample type serum
sample type culture supernatant(s)
sample type plasma
sample type cell lysate

assay range

inter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 0.125 pg/mL
standard curve range: 0.1–1000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GIP(2695)

General description

Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid gastrointestinal regulatory peptide, expressed in K cells of the small intestine and in cells of the submandibular salivary gland.

Immunogen

Gastric Inhibitory Peptide (GIP), synthetic peptide

Application

Gastric inhibitory peptide has been used in enzyme immunoassay.

Biochem/physiol Actions

In the presence of glucose, glucose-dependent insulinotropic polypeptide (GIP) induces insulin secretion. It acts as an antagonist of the human GIP receptor. Aberrations in GIP are associated with visceral fat accumulation.

Kit Components Also Available Separately

Product No.
Description
SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Regulatory Information

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The gluco-and liporegulatory and vasodilatory effects of glucose-dependent insulinotropic polypeptide (GIP) are abolished by an antagonist of the human GIP receptor.
Asmar M, et al.
Diabetes, 66(9), 2363-2371 (2017)
Incretin hormones receptor signaling plays the key role in antidiabetic potential of PTY-2 against STZ-induced pancreatitis.
Srivastava S, et al.
Biomedicine and Pharmacotherapy, 97, 330-338 (2018)
Tao Hao et al.
International journal of molecular medicine, 39(4), 1029-1036 (2017-03-16)
Long-term exposure to a high-fat diet (HFD) causes glucotoxicity and lipotoxicity in islet β cells and leads to the development of metabolic dysfunctions. Reductions in pancreatic and duodenal homeobox-1 (PDX-1) expression have been shown to induce type 2 diabetes mellitus by causing impairments to
Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene in a mouse neuroendocrine tumor cell line.
Boylan MO, et al.
The Journal of Biological Chemistry, 272(28), 17438-17443 (1997)
Common variants of GIP are associated with visceral fat accumulation in Japanese adults.
Nakayama K, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 307(11), G1108-G1114 (2014)
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