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RAB0201

Sigma-Aldrich

GLP-1 EIA Kit

for serum, plasma, culture supernatant and cell lysates

Synonym(s):

Glucagon-like-peptide 1

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

species reactivity

human, rat, mouse

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
enzyme immunoassay: suitable

input

sample type cell lysate
sample type plasma
sample type serum
sample type culture supernatant(s)

assay range

inter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 1.17 pg/mL
standard curve range: 0.1–1000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GCG(2641)

General description

The GLP-1 Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting GLP-1 peptide based on the principle of Competitive Enzyme Immunoassay.

Immunogen

Glucagon-like Peptide 1 (GLP-1), synthetic peptide

Application

For research use only. Not for use in diagnostic procedures.

Biochem/physiol Actions

Glucagon-Like Peptide I (GLP1) controls the metabolism of glucose by inducing the secretion of insulin and suppressing that of glucagon. Studies in Indonesian population show that reduced levels of this protein are linked with increased susceptibility to type 2 diabetes mellitus. Plasma levels of this hormone also show significant association with systolic and diastolic blood pressure levels.

Kit Components Also Available Separately

Product No.
Description
SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

WGK

WGK 3

Regulatory Information

常规特殊物品
含少量动物源组分生物产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maria F Fernandes et al.
International journal of molecular sciences, 23(8) (2022-04-24)
Glucagon-like peptide-1 (GLP-1) potentiates glucose-stimulated insulin secretion (GSIS). While dozens of compounds stimulate GLP-1 secretion, few inhibit. Reduced GLP-1 secretion and impaired GSIS occur in chronic inflammation. Lysophosphatidic acids (LPAs) are bioactive phospholipids elevated in inflammation. The aim of this
Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors
Li AJ, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 310(8), R724-R732 (2016)
Ai-Jun Li et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 310(8), R724-R732 (2016-01-23)
Mercaptoacetate (MA) is an orexigenic agent reported to block fatty acid (FA) oxidation. Recently, however, we reported evidence from isolated nodose ganglion neurons that MA antagonizes the G protein-coupled long- and medium-chain FA receptor GPR40. GPR40 mediates FA-induced secretion of
Jennifer O Adeghate et al.
Cells, 10(8) (2021-08-28)
The effects of early (5-day) onset of diabetes mellitus (DM) on retina ultrastructure and cellular bioenergetics were examined. The retinas of streptozotocin-induced diabetic rats were compared to those of non-diabetic rats using light and transmission electron microscopy. Tissue localization of
Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient
Beumer J, et al.
Nature Cell Biology, 20(8), 909-909 (2018)
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