RAB0160
Human EGFR / ErbB1 ELISA Kit
for serum, plasma, cell culture supernatants and urine
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type urine
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 4 pg/mL
standard curve range: 2.74-2000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... EGFR(1965)
General description
Epidermal growth factor receptor (EGFR) is a member of the epidermal growth factor receptor tyrosine kinase (RTK) family. It is a single-chain transmembrane glycoprotein. EGFR comprises an extracellular ligand-binding ectodomain, a short juxtamembrane section, a transmembrane domain, a tyrosine kinase domain, tyrosine-containing C-terminal tail. Overexpression of EGFR is observed in breast cancer cells.
Immunogen
Recombinant Human EGFR
Application
Human EGFR / ErbB1 ELISA Kit has been used in the estimation of epidermal growth factor receptors (EGFR) from human epithelial cells. It has also been used in the detection of EGFR from patient plasma/serum and exosomes isolated from human prostate cancer cells LNCaP xenografts.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Description
SDS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Regulatory Information
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Geetanjali Kharmate et al.
PloS one, 11(5), e0154967-e0154967 (2016-05-07)
Exosomes proteins and microRNAs have gained much attention as diagnostic tools and biomarker potential in various malignancies including prostate cancer (PCa). However, the role of exosomes and membrane-associated receptors, particularly epidermal growth factor receptor (EGFR) as mediators of cell proliferation
Ayelet Zlotogorski-Hurvitz et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 63(3), 181-189 (2014-12-05)
ExoQuick-TC(TM) (EQ), a chemical-based agent designed to precipitate exosomes, was calibrated for use on saliva collected from healthy individuals. The morphological and molecular features of the precipitations were compared with those obtained using the classical, physical-based method of ultracentrifugation (UC).
Taketo Uchiyama et al.
BMC nephrology, 21(1), 219-219 (2020-06-11)
Chronic kidney disease (CKD) disrupts mineral homeostasis and its main underlying cause is secondary hyperparathyroidism (SHPT). We previously reported that calcium-sensing receptor (CaSR) mRNA and protein expression in parathyroid glands (PTGs) significantly decreased in a CKD rat model induced by
S K Muthuswamy et al.
Nature cell biology, 3(9), 785-792 (2001-09-05)
Both ErbB1 and ErbB2 are overexpressed or amplified in breast tumours. To examine the effects of activating ErbB receptors in a context that mimics polarized epithelial cells in vivo, we activated ErbB1 and ErbB2 homodimers in preformed, growth-arrested mammary acini
M J Wieduwilt et al.
Cellular and molecular life sciences : CMLS, 65(10), 1566-1584 (2008-02-09)
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors carry out both redundant and restricted functions in mammalian development and in the maintenance of tissues
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