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R9653

Sigma-Aldrich

RC-3095

≥95% (HPLC), lyophilized powder

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Synonym(s):
(3R)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-Ψ(CH2-NH)-L-Leucinamide triflouroacetate salt, (D-Tpi6, Leu13Ψ(CH2-NH)-Leu14)bombesin (6-14), D-Tpi-Gln-Trp-Ala-Val-Gly-His-Y(CH2-NH)-Leu-NH2 trifluoroacetate salt trifluoroacetate salt, (D-Tpi6, Leu13 Ψ(CH2-NH)-Leu14)bombesin (6-14), D-Tpi-Gln-Trp-Ala-Val-Gly-His-Leu-Y(CH2-NH)-Leu-NH2 trifluoroacetate salt
Empirical Formula (Hill Notation):
C56H79N15O9 · xC2HF3O2
CAS Number:
138147-78-1
Molecular Weight:
1106.32 (free base basis)
MDL number:
MFCD07366644
UNSPSC Code:
12352200
PubChem Substance ID:
24899418
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized powder

color

white to off-white

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]4Cc5c(CN4)[nH]c6ccccc56)C(C)C

InChI

1S/C56H79N15O9.C2HF3O2/c1-29(2)18-35(25-61-42(50(58)74)19-30(3)4)66-55(79)45(21-34-24-59-28-64-34)68-48(73)27-63-56(80)49(31(5)6)71-51(75)32(7)65-54(78)44(20-33-23-60-39-14-10-8-12-36(33)39)70-52(76)41(16-17-47(57)72)69-53(77)43-22-38-37-13-9-11-15-40(37)67-46(38)26-62-43;3-2(4,5)1(6)7/h8-15,23-24,28-32,35,41-45,49,60-62,67H,16-22,25-27H2,1-7H3,(H2,57,72)(H2,58,74)(H,59,64)(H,63,80)(H,65,78)(H,66,79)(H,68,73)(H,69,77)(H,70,76)(H,71,75);(H,6,7)/t32-,35-,41-,42-,43+,44-,45-,49-;/m0./s1

InChI key

ZHNRKEKBKBWCMF-RWWZSYIDSA-N

Related Categories

Amino Acid Sequence

(D-TPI6, LEU13 y(CH2-NH)-LEU14)BOMBESIN (6-14)

Biochem/physiol Actions

RC-3095 is a potent BB2 (GRP-preferring) bombesin receptor antagonist.

Packaging

Air sensitive

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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Gislaine T Rezin et al.
Basic & clinical pharmacology & toxicology, 108(3), 214-219 (2010-12-09)
The pathophysiology of gastritis involves an imbalance between gastric acid attack and mucosal defence. In addition, the gastric mucosal injury results in adenosine triphosphate (ATP) depletion leading to mitochondrial dysfunction. Several studies have shown the association of mitochondrial disorders with
Vanessa A Garcia et al.
Behavioural brain research, 214(2), 456-459 (2010-08-04)
Alterations in attachment behavior might play a role in the dysfunction in social behavior displayed by autistic infants. Here we show that neonatal gastrin-releasing peptide receptor (GRPR) blockade induces a reduction in maternal odor preference, a task involving attachment behavior
Fabricia Petronilho et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(9), 783-789 (2010-04-07)
We report the effects of the gastrin-releasing peptide (GRP) receptor antagonist RC-3095 in an acute inflammation model induced by carrageenan. Male Wistar rats received saline or saline containing 2% lambda-carrageenan into the pleural cavity, with some also receiving RC-3095 3
P G Oliveira et al.
Arthritis and rheumatism, 63(10), 2956-2965 (2011-09-29)
To evaluate the antiinflammatory effects of RC-3095 in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA), and to determine the mechanisms of action involved. RC-3095 was administered daily to mice with CIA and mice with AIA
Caroline Brunetto de Farias et al.
Protein and peptide letters, 16(6), 650-652 (2009-06-13)
The gastrin-releasing peptide receptor (GRPR) is a therapeutic target in colon cancer. Here we show that the GRPR antagonist RC-3095 (10(-3), 10(-6), or 1 microM) decreases nerve growth factor (NGF) secretion measured by enzyme-linked immunosorbent assay (ELISA) in HT-29 human
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