R9400
Monoclonal Anti-RANTES antibody produced in rat
clone 53405.111, purified immunoglobulin, lyophilized powder
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Synonym(s):
Anti-D17S136E, Anti-RANTES, Anti-SCYA5, Anti-SIS-delta, Anti-SISd, Anti-TCP228, Anti-eoCP
Recommended Products
biological source
rat
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
53405.111, monoclonal
form
lyophilized powder
purified by
using protein G
species reactivity
mouse
technique(s)
immunocytochemistry: 8-25 μg/mL using mouse splenocytes
neutralization: suitable
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Ccl5(20304)
Related Categories
Immunogen
purified, E. coli-derived, recombinant mouse RANTES.
Biochem/physiol Actions
RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose pH 7.4.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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F Villalta et al.
Infection and immunity, 66(10), 4690-4695 (1998-09-24)
This paper describes a new role for the cysteine-cysteine (CC) chemokines RANTES, MIP-1alpha, and MIP-1beta on human macrophage function, which is the induction of nitric oxide (NO)-mediated trypanocidal activity. In a previous report, we showed that RANTES, MIP-1alpha and MIP-1beta
Alan M Krensky et al.
Nature clinical practice. Nephrology, 3(3), 164-170 (2007-02-27)
Chemokines (chemoattractant cytokines) are fundamental regulators of immune cell movement from the bloodstream into tissues. Regulating expression of chemokines might, therefore, alleviate inflammation in autoimmune diseases and transplant rejection, or augment immune responses in cancer and immunodeficiency. RANTES (regulated upon
V Appay et al.
Trends in immunology, 22(2), 83-87 (2001-04-05)
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some
The unexpected pleiotropic activities of RANTES.
Jay A Levy
Journal of immunology (Baltimore, Md. : 1950), 182(7), 3945-3946 (2009-03-21)
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