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Merck
CN

R7882

Retinyl acetate

solid or viscous liquid, BioReagent, synthetic, suitable for cell culture

Synonym(s):

Retinol acetate, Vitamin A acetate

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About This Item

Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
127-47-9
Molecular Weight:
328.49
NACRES:
NA.75
PubChem Substance ID:
24899401
eCl@ss:
34058009
UNSPSC Code:
12352205
EC Number:
204-844-2
MDL number:
MFCD00019413
Beilstein/REAXYS Number:
1915439

Key Documents

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Product Name

Retinyl acetate, solid or viscous liquid, BioReagent, synthetic, suitable for cell culture

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

biological source

synthetic

product line

BioReagent

assay

≥90% (HPLC)

form

solid or viscous liquid

potency

~2,800,000 I.U. per g

mol wt

Mw 328.49 g/mol

technique(s)

cell culture | mammalian: suitable

color

light yellow to dark yellow

mp

57-58 °C

solubility

absolute ethanol: 25 mg/mL (lit.)

storage temp.

−20°C

Quality Level

200

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Application

Retinyl acetate has been used as a standard to measure the concentration of vitamin C in high performance liquid chromatography analysis (HPLC) and as a supplement in the preparation of the complete medium.

Biochem/physiol Actions

The oxidized form of retinol is retinoic acid, which has hormone-like growth factor and differentiation activity for epithelial and related cell types, especially neural cells. Retinoic acid induces embryonic stem cells to differentiate towards neural cells. Retinyl-acetate is known to be effective in treating breast cancer.

General description

Retinyl-acetate is a natural and ester derivative of vitamin A. It is found in classical media formulations such as M-199; NCTC-109 and William′s Medium E. Vitamin A is a component of serum useful in most serum containing cell culture systems, which receive some level of vitamin A.

Other Notes

All trans

Preparation Note

The melting point of this material is approx. 58 °C. In order to package, it was melted and may exist as a crystalline solid or as a supercooled viscous liquid.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
0000481217
0000481217
0000429445
0000429444
0000429444

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Changes in the composition of yak colostrum during the first week of lactation
Mi JD, et al.
Journal of Dairy Science, 99(1), 818-824 (2016)
Hormones and Vitamins in Cancer Treatment, 247-247 (1990)
Yong Ho Jo et al.
Asian-Australasian journal of animal sciences, 33(5), 742-752 (2020-02-15)
This study investigated the effects of vitamin A (VA) supplementation during late-stage pregnancy on longissimus dorsi muscle tissue development, birth traits, and growth performance of postnatal Korean native calves. In the preliminary experiment, twenty-six pregnant cattle (initial body weight [BW]
Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level
Ortega F, et al.
Nature Protocols, 6(12), 1847-1847 (2011)
Fei He et al.
Stem cell research & therapy, 11(1), 163-163 (2020-04-30)
Human embryonic stem cells represent a potentially unlimited source of insulin-producing cells for diabetes therapy. While tremendous progress has been made in directed differentiation of human embryonic stem cells into IPCs in vitro, the mechanisms controlling its differentiation and function
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