R7502
Roridin A from Myrothecium sp.
powder, ≥98% (TLC)
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About This Item
Empirical Formula (Hill Notation):
C29H40O9
CAS Number:
Molecular Weight:
532.62
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
238-783-8
MDL number:
SMILES string
CC(O)C1OCCC(C)C(O)C(=O)OCC23CCC(C)=CC2OC4CC(OC(=O)\C=C\C=C\1)C3(C)C45CO5
assay
≥98% (TLC)
form
powder
solubility
chloroform: ≥10 mg/mL, clear, colorless
storage temp.
−20°C
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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B Yagen et al.
Experientia, 43(8), 886-888 (1987-08-15)
Several trichothecene mycotoxins were shown to inhibit the growth of Saccharomyces cerevisiae. This effect was most pronounced with the macrocyclic trichothecenes, especially verrucarin A. Much less growth inhibition was observed with T-2 toxin. Verrucarol, diacetoxyscirpenol, acetyl T-2 toxin, HT-2 toxin
Kara N Corps et al.
Toxicologic pathology, 38(3), 429-451 (2010-05-01)
Macrocyclic trichothecene mycotoxins encountered in water-damaged buildings have been suggested to contribute to illnesses of the upper respiratory tract. Here, the authors characterized the adverse effects of repeated exposures to roridin A (RA), a representative macrocyclic trichothecene, on the nasal
Isolation of a mycotoxin (roridin A) from Phomopsis spp.
D Samples et al.
Veterinary and human toxicology, 26(1), 21-23 (1984-02-01)
J K Bubien et al.
Toxicon : official journal of the International Society on Toxinology, 25(3), 325-331 (1987-01-01)
Intravenous injection of T-2 toxin or roridin-A (2 mg/kg) into pentobarbital-anesthetized (30 mg/kg) dogs produced, respectively, decreased systolic pressure within 30 min and atrio-ventricular block within 60 min. Within 45 +/- 15 min after injection of each toxin heart rate
J J Pestka et al.
Toxicology letters, 41(3), 215-222 (1988-06-01)
The effect of in vitro exposure to the macrocyclic trichothecenes roridin A and verrucarin A on human lymphocyte transformation was evaluated in the mitogen-induced blastogenesis assay. Both compounds were capable of inhibiting stimulation of B- and T-cell subsets by a
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