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Merck
CN

R7017

Resazurin sodium salt

powder, BioReagent

Synonym(s):

7-Hydroxy-3H-phenoxazin-3-one-10-oxide sodium salt

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About This Item

Empirical Formula (Hill Notation):
C12H6NNaO4
CAS Number:
62758-13-8
Molecular Weight:
251.17
Beilstein:
3794971
EC Number:
263-718-5
MDL number:
MFCD00005036
UNSPSC Code:
12352207
PubChem Substance ID:
24899387
NACRES:
NA.75

Key Documents

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product line

BioReagent

Quality Level

200

form

powder

composition

Dye content, ~80%

pH

3.8-6.5, orange to violet

solubility

H2O: soluble

λmax

600 nm

SMILES string

[Na+].[O-]c1ccc2c(OC3=CC(=O)C=CC3=[N+]2[O-])c1

InChI

1S/C12H7NO4.Na/c14-7-1-3-9-11(5-7)17-12-6-8(15)2-4-10(12)13(9)16;/h1-6,14H;/q;+1/p-1

InChI key

IVGPGQSSDLDOLH-UHFFFAOYSA-M

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Application

For the measurement of metabolic activity and proliferation of living cells. The bioreduction of the dye reduces the amount of the oxidized form (blue) and concomitantly increases the fluorescent intermediate (red).
Resazurin sodium salt has been used in viability assay:
  • to measure cell viability of A. fumigatus
  • to assess cell proliferation
  • to determine A. fumigatus viability in high-throughput screenings of microbial natural extracts

Biochem/physiol Actions

Resazurin is a blue, non-fluorescent dye originally used to test milk/biological fluids for bacterial and yeast contamination. It is also useful in sperm viability and semen quality test. Resazurin is applicable in cytotoxicity determination.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000321963
0000305141
0000305141
0000321963
SHBR8098

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Sugandha Bhatia et al.
Journal of clinical medicine, 8(6) (2019-06-27)
Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have delineated epithelial and mesenchymal subpopulations existing within the PMC42-LA breast cancer cell line by their EpCAM expression. These
Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010)
Valiante V, et al.
Antimicrobial agents and chemotherapy, 59(9), 5145-5153 (2015)
Julianna Siciliano de Araújo et al.
Antimicrobial agents and chemotherapy, 63(4) (2019-01-24)
More than 100 years after being first described, Chagas disease remains endemic in 21 Latin American countries and has spread to other continents. Indeed, this disease, which is caused by the protozoan parasite Trypanosoma cruzi, is no longer just a problem
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
O Brien J, et al.
European Journal of Biochemistry, 267(17), 5421-5426 (2000)
Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb
Chao DT, et al.
Journal of Cancer Research and Clinical Oncology, 139, 315?325-315?325 (2012)
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