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R4655

Sigma-Aldrich

Anti-Rab27 (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-RAB27A, member RAS oncogene family

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100 μL
¥4,239.58

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100 μL
¥4,239.58

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

¥4,239.58

Please contact Customer Service for Availability
New, lower price on this item!
Request a Bulk Order

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~25 kDa

species reactivity

human, rat

concentration

~1.5 mg/mL

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Anti-Rab27 (N-terminal) antibody produced in rabbit ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

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Anti-Rab9 from rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

R5279

Anti-Rab9 from rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... RAB27A(5873)
rat ... Rab27a(50645)

Gene Information

human ... RAB25(57111)

Gene Information

human ... RAB14(51552)
mouse ... Rab14(68365)
rat ... Rab14(94197)

Gene Information

human ... RAB9A(9367)
mouse ... Rab9(56382)
rat ... Rab9a(84589)

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

General description

Rab27 (Ras-related protein) is a member of the Rab family of small guanosine triphosphatases (GTPases). Rab27 is widely expressed in non-neuronal regulated secretory cells, including exocrine, endocrine, ovarian, and hematopoietic cells.
Rab27A (Ras-related protein) belongs to the Rab family of small GTPase proteins. It is located on chromosome 15q21.

Immunogen

synthetic peptide corresponding to amino acid residues 45-57 of human RAB27A, with an added cysteine, conjugated to KLH. The corresponding sequence differs by one amino acid in rat and mouse Rab27A and by 2 amino acids in human RAB27B.

Application

Anti-Rab27 (N-terminal) antibody has been used in immunoblotting, immunofluorescence.

Biochem/physiol Actions

In humans, Rab27A (Ras-related protein) plays important roles in the development of cancers. It is considered as a prognostic biomarker for CRC (colorectal cancer) patients. It may participate in the transfer of protein and signal transduction mediated by GTPase. Rab27 mutation is linked with Griscelli syndrome type 2. It is also responsible for the innate immune resistance against invading microorganisms.
Rab27 (Ras-related protein) regulates the exocytosis of these cell-specific store organelles, using multiple organelle-specific effector proteins, such as granuphilin and melanophilin.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    027M4855V
    076M4777V
    058K4832

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    Rab27a was identified as a prognostic biomaker by mRNA profiling, correlated with malignant progression and subtype preference in gliomas
    Wang H, et al.
    PLoS ONE, 9(2) (2014)
    High Rab27A expression indicates favorable prognosis in CRC
    Shi C, et al.
    Diagnostic Pathology, 10:68 (2015)
    Vectorial release of hepatitis E virus in polarized human hepatocytes
    Capelli N, et al.
    Journal of virology, 93(4), e01207-e01218 (2019)
    Bong Hwan Sung et al.
    Nature communications, 6, 7164-7164 (2015-05-15)
    Directional cell movement through tissues is critical for multiple biological processes and requires maintenance of polarity in the face of complex environmental cues. Here we use intravital imaging to demonstrate that secretion of exosomes from late endosomes is required for
    Seema Sinha et al.
    The Journal of cell biology, 214(2), 197-213 (2016-07-13)
    Exosomes are extracellular vesicles that influence cellular behavior and enhance cancer aggressiveness by carrying bioactive molecules. The mechanisms that regulate exosome secretion are poorly understood. Here, we show that the actin cytoskeletal regulatory protein cortactin promotes exosome secretion. Knockdown or
    View All Related Papers

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