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R4127

Sigma-Aldrich

Rhodamine 6G

Dye content ~95 %, Powder

Synonym(s):

Basic Red 1

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About This Item

Linear Formula:
C28H31N2O3Cl
CAS Number:
989-38-8
Molecular Weight:
479.01
Colour Index Number:
45160
Beilstein:
3900071
EC Number:
213-584-9
MDL number:
MFCD00012665
UNSPSC Code:
12171500
PubChem Substance ID:
24899367
NACRES:
NA.47

product name

Rhodamine 6G, Dye content ~95 %

form

powder

Quality Level

200

composition

Dye content, ~95%

mp

215 °C

solubility

H2O: 1 mg/mL (Red to Very Dark Red)

density

1.3 g/cm3

εmax

≥1700 at 525 nm in water

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cl.CCNc1cc2OC3=CC(=N/CC)\C(C)=CC3=C(c2cc1C)c4ccccc4C(=O)OCC

InChI

1S/C28H30N2O3.ClH/c1-6-29-23-15-25-21(13-17(23)4)27(19-11-9-10-12-20(19)28(31)32-8-3)22-14-18(5)24(30-7-2)16-26(22)33-25;/h9-16,29H,6-8H2,1-5H3;1H/b30-24+;

InChI key

VYXSBFYARXAAKO-WTKGSRSZSA-N

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Application

Rhodamine 6G has been used as a leukocyte marker to study the interaction between leukocytes and the vascular endothelium. It has also been used to label platelets.

Biochem/physiol Actions

Rhodamine 6G is a rhodamine analog useful in P-glycoprotein (Pgp) efflux assays. It has been used to characterize kinetics of multidrug resistance protein 1 (MRP1)-mediated efflux.
A rhodamine analog useful in Pgp efflux assays. Has been used to characterize kinetics of MRP1- mediated efflux.

Signal Word

Danger

Hazard Statements

H301,H317,H318,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Şefik E Erdener et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 41(2), 236-252 (2020-04-03)
Ever since the introduction of thrombolysis and the subsequent expansion of endovascular treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are less favorable despite recanalization. Here, by high spatio-temporal resolution imaging of capillary circulation
Kinetic Analysis of Rhodamines Efflux Mediated by the Multidrug Resistance Protein (MRP1)
Chantarawan S
Biophysical Journal, 85(3) (2003)
Impact of pore size on the vascularization and
osseointegration of ceramic bone substitutes in vivo
Frank M. Klenke
Journal of Biomedical Materials Research (2007)
Interaction of Kupffer Cells and Platelets Determines the Severity of Ischemia-Reperfusion Injury in Steatosis
Koichi Ogawa
The Tohoku Journal of Experimental Medicine, 232 (2014)
Induction of P-Glycoprotein by Antiretroviral Drugs in Human Brain Microvessel Endothelial Cells
Gary N.Y. Chan
Antimicrobial Agents and Chemotherapy, 57(9) (2013)
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