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R3654

Sigma-Aldrich

Anti-RbAp48 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Retinoblastoma-binding protein

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About This Item

MDL number:
MFCD02686588
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: 1-2 μg/mL using HeLa cells fixed with paraformaldehyde-Triton
western blot: 0.5-1 μg/mL using MCF7 nuclear extracts

UniProt accession no.

Q09028

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RBBP4(5928)
mouse ... Rbbp4(19646)
rat ... Rbbp4(313048)

General description

Histone binding protein (RbAp48, also known as also known as RBBP4 or NURF55) contains 425 amino acids, tryptophan-aspartic acid (WD)-domain containing protein isolated as a retinoblastoma binding protein (RB1).

Immunogen

synthetic peptide corresponding to amino acids 1-14 of human RbAp48, conjugated to KLH via a C-terminal added cysteine residue. The immunizing peptide is conserved in human, mouse, and rat.

Application

Anti-RbAp48 antibody produced in rabbit has been used in immunoprecipitation and western blot analysis. It may also be used in immunofluorescence.

Biochem/physiol Actions

RbAp48 is found in association with chromatin remodeling complexes Sin3A/histone deacetylase (HDAC) and NURD (nucleosomal remodeling and deacetylation complex).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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WGK

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Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus
Viiri KM, et al.
Nucleic Acids Research, 34(11), 3288-3288 (2006)
Gohei Nishibuchi et al.
The Journal of biological chemistry, 289(42), 28956-28970 (2014-09-06)
Histone H3K4 methylation has been linked to transcriptional activation. KDM5A (also known as RBP2 or JARID1A), a member of the KDM5 protein family, is an H3K4 demethylase, previously implicated in the regulation of transcription and differentiation. Here, we show that

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