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R1753

Sigma-Aldrich

Ribonucleic acid, transfer from Escherichia coli

Type XX, Strain W, lyophilized powder

Synonym(s):

Transfer RNA, tRNA

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About This Item

CAS Number:
9014-25-9
MDL number:
MFCD00132200
UNSPSC Code:
41106305
NACRES:
NA.51

Quality Level

200

type

Type XX

form

lyophilized powder

storage temp.

−20°C

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Application

Ribonucleic acid, transfer from Escherichia coli, Type XX, Strain W may be used as a starting material for the purification of specific amino acyl-tRNA species by methods such as liquid column chromatography or high-performance liquid chromatography (HPLC).

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 mL of water (1 cm light path).

Analysis Note

Each lot is evaluated for its amino acid acceptor activity using aminoacyl-tRNA synthetase and Arg.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How many mgs of tRNA, Product R1753, come in the 100UN, 500UN, 2KU and 10KU package sizes?

    The amount of powder will vary between lots depending on the activity.  For example, a Certificate of Analysis of a lot may say 18 A260 units/mg solid.  This means that the 100UN package will contain approxomately 5.56 mg of solid.

  6. Can Product R1753, tRNA, be used in molecular biology applications?

    This product has not been tested for Dnase or RNase activity. Product Nos. R5636 and R8508 are from baker's yeast; they have been tested for DNase and Nickase.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Roya Pedram Fatemi et al.
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Long non-protein coding RNAs (lncRNAs) are an important class of molecules that help orchestrate key cellular events. Although their functional roles in cells are not well understood, thousands of lncRNAs and a number of possible mechanisms by which they act
Miguel López-Estepa et al.
PloS one, 10(4), e0118606-e0118606 (2015-04-22)
Cyclic N6-threonylcarbamoyladenosine ('cyclic t6A', ct(6)A) is a non-thiolated hypermodification found in transfer RNAs (tRNAs) in bacteria, protists, fungi and plants. In bacteria and yeast cells ct(6)A has been shown to enhance translation fidelity and efficiency of ANN codons by improving
Kirill Kondratov et al.
Journal of extracellular vesicles, 9(1), 1743139-1743139 (2020-04-29)
The aim of this study was to investigate cell source-dependent nucleic acids repertoire of diverse subpopulations of plasma extracellular vesicles (EVs). Blood plasma from nine healthy volunteers was used for the analysis. Samples of EVs were obtained by differential centrifugation
Thomas E Sladewski et al.
eLife, 7 (2018-06-27)
We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding protein Egalitarian (Egl) and K10 mRNA cargo were
Adi Egozi et al.
Cell reports, 32(7), 108043-108043 (2020-08-20)
The islets of Langerhans are dynamic structures that can change in size, number of cells, and molecular function in response to physiological and pathological stress. Molecular cues originating from the surrounding "peri-islet" acinar cells that could facilitate this plasticity have
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