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Safety Information

R106

Sigma-Aldrich

Ro 16-6491 hydrochloride

solid

Synonym(s):

N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H11ClN2O · HCl
CAS Number:
94319-79-6
Molecular Weight:
235.11
MDL number:
MFCD00078595
UNSPSC Code:
12352200
PubChem Substance ID:
329823996

form

solid

color

white

mp

216-217 °C

solubility

H2O: soluble

SMILES string

Cl.NCCNC(=O)c1ccc(Cl)cc1

InChI

1S/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H

InChI key

ARUMZUNJBHSOQQ-UHFFFAOYSA-N

Gene Information

human ... MAOB(4129)

Biochem/physiol Actions

Selective, reversible, orally-active MAO-B inhibitor which is devoid of indirect sympathomimetic activity.

comparable product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Ro 16-6491: a new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP.
M Da Prada et al.
Advances in neurology, 45, 175-178 (1987-01-01)
A M Cesura et al.
Journal of neurochemistry, 48(1), 170-176 (1987-01-01)
The reversible inhibitor of monoamine oxidase type B (MAO-B) [3H]Ro 16-6491 binds specifically and with high affinity to a single population of binding sites in human frontal cortex crude mitochondria and platelet membranes. In both tissues binding equilibrium was reached
E L Mullan et al.
Journal of neural transmission. Supplementum, 41, 307-311 (1994-01-01)
Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro
A M Cesura et al.
Journal of neurochemistry, 50(4), 1037-1043 (1988-04-01)
[3H]Ro 16-6491 [N-(2-aminoethyl)-p-chlorobenzamide HCl], a reversible "mechanism-based" inhibitor of monoamine oxidase (MAO) type B, binds selectively and with high affinity to the active site of MAO-B in brain and platelet membranes. Under normal conditions, the binding of [3H]Ro 16-6491 is
Interactions of the novel inhibitors of MAO-B Ro 19-6327 and Ro 16-6491 with the active site of the enzyme.
A M Cesura et al.
Pharmacological research communications, 20 Suppl 4, 51-61 (1988-12-01)
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