Skip to Content
Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

R0529

Sigma-Aldrich

Ro 90-7501

≥98% (HPLC)

Synonym(s):

2′-(4-Aminophenyl)-[2,5′-bi-1H-benzimidazol]-5-amine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C20H16N6
CAS Number:
293762-45-5
Molecular Weight:
340.38
MDL number:
MFCD00367977
UNSPSC Code:
12352200
PubChem Substance ID:
24724587

Assay

≥98% (HPLC)

form

solid

color

brown

solubility

DMSO: ~20 mg/mL
H2O: insoluble

originator

Roche

SMILES string

Nc1ccc(cc1)-c2nc3ccc(cc3[nH]2)-c4nc5ccc(N)cc5[nH]4

InChI

1S/C20H16N6/c21-13-4-1-11(2-5-13)19-23-15-7-3-12(9-17(15)25-19)20-24-16-8-6-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26)

InChI key

PAGZCEHLFCJSPV-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibitor of Aß42 fibril formation

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
035K4715

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

B Bohrmann et al.
Journal of structural biology, 130(2-3), 232-246 (2000-08-15)
Assemblyof the amyloid-beta peptide (Abeta) into fibrils and its deposition in distinct brain areas is considered responsible for the pathogenesis of Alzheimer's disease (AD). Thus, inhibition of fibril assembly is a potential strategy for therapeutic intervention. Electron cryomicroscopy was used
Christopher A Ross et al.
Nature medicine, 10 Suppl, S10-S17 (2004-07-24)
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation. The aggregates
Katelyn E Zulauf et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(47), 29839-29850 (2020-11-11)
Carbapenem-resistant Enterobacteriaceae (CRE) are multidrug-resistant pathogens for which new treatments are desperately needed. Carbapenemases and other types of antibiotic resistance genes are carried almost exclusively on large, low-copy-number plasmids (pCRE). Accordingly, small molecules that efficiently evict pCRE plasmids should restore
Zhihao Li et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 148, 21-29 (2020-04-21)
Radiotherapy plays a crucial role in the treatment of cervical cancer, but existing radiosensitizers have limited efficacy in clinical applications. The aims of this study were to establish and verify an efficient method for identifying new radiosensitizers, to use this
Sally Park et al.
Small GTPases, 12(2), 147-160 (2019-10-12)
Rho proteins are signalling molecules that control cellular dynamics, movement and morphological changes. They are activated by Rho guanine-nucleotide exchange factors (Rho GEFs) that transduce upstream signals into Rho-mediated activation of downstream processes. Fgd5 is a Rho GEF involved in
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service