Q0380
Quinone Oxidoreductase 2 (NQO2) human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥100 units/mg protein
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Synonym(s):
NQO2 human, NRH nitroreductase human, NRH quinone reductase human
Recommended Products
recombinant
expressed in E. coli
Quality Level
Assay
≥90% (SDS-PAGE)
form
lyophilized powder (one vial contains one mg protein)
specific activity
≥100 units/mg protein
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... NQO2(4835)
Application
Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.
The product from Sigma has been used to identify novel inhibitors of the enzyme NQO2. It has also been used to investigate the effect of afobazole on quinone reductase 2 activity.
Biochem/physiol Actions
Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.
Unique human oxidoreductase that uses Dihydronicotinamide riboside (NRH) as a cosubstrate, not NAD(P)H. Activates anticancer prodrugs. Putative melatonin receptor.
Unit Definition
One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 °C.
Physical form
contains 10% PBS buffer salts
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Paraquat Research. Do Recent Advances In Limiting Its Toxicity Make Its Use Safer?
Baltazar, T., et al.
British Journal of Pharmacology (2012)
Effect of Afobazole on Activity of Quinone Reductase 2
Kadnikov IA, et al.
Pharmaceutical Chemistry Journal, 47(10), 514-516 (2014)
Karen A Nolan et al.
Molecular cancer therapeutics, 11(1), 194-203 (2011-11-18)
The National Cancer Institute chemical database has been screened using in silico docking to identify novel nanomolar inhibitors of NRH:quinone oxidoreductase 2 (NQO2). The inhibitors identified from the screen exhibit a diverse range of scaffolds and the structure of one
K A Nolan et al.
Bioorganic & medicinal chemistry letters, 20(9), 2832-2836 (2010-04-02)
The purpose of the work was to identify novel inhibitors of the enzyme NQO2. Using computational molecular modelling, a QSAR (R(2)=0.88) was established, relating inhibitory potency with calculated binding affinity. From this, the imidazoacridin-6-one, NSC660841, was identified as the most
Qiuying Cheng et al.
Biochemical pharmacology, 83(1), 139-148 (2011-10-18)
Carbonyl reductase activity catalyzes the two electron reduction of several endogenous and exogenous carbonyl substrates. Recent data indicate that the expression of human carbonyl reductase 3 (CBR3) is regulated by the master redox switch Nrf2. Nrf2 binds to conserved antioxidant
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