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PZ0369

Sigma-Aldrich

PF-04217329

≥98% (HPLC)

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Synonym(s):
2-[3-[[[[4-(1H-Pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-acetic acid 1-methylethyl ester, Isopropyl 2-[3-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](pyridin-3-ylsulfonyl)amino]methyl]phenoxy]acetate, PF 04217329, Taprenepag isopropyl
Empirical Formula (Hill Notation):
C27H28N4O5S
CAS Number:
1005549-94-9
Molecular Weight:
520.60
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

O=S(N(CC1=CC=C(N2N=CC=C2)C=C1)CC3=CC=CC(OCC(OC(C)C)=O)=C3)(C4=CC=CN=C4)=O

InChI

1S/C27H28N4O5S/c1-21(2)36-27(32)20-35-25-7-3-6-23(16-25)19-30(37(33,34)26-8-4-13-28-17-26)18-22-9-11-24(12-10-22)31-15-5-14-29-31/h3-17,21H,18-20H2,1-2H3

InChI key

NVPXUFQLKWKBHK-UHFFFAOYSA-N

Biochem/physiol Actions

PF-04217329 is a selective and potent prostaglandin EP2 receptor agonist. PF-04217329 is an ocular bioavailable isopropyl ester prodrug of CP-544326 (active acid metabolite).

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Gina M Yanochko et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 30(5), 429-439 (2014-04-12)
Taprenepag isopropyl is an EP2 receptor agonist that is in development for the treatment of glaucoma. Iritis, photophobia, and increased corneal thickness observed in a Phase 2 clinical trial with taprenepag isopropyl were not previously observed in topical ocular toxicity
Ganesh Prasanna et al.
Experimental eye research, 93(3), 256-264 (2011-03-08)
Better control of intraocular pressure (IOP) is the most effective way to preserve visual field function in glaucomatous patients. While prostaglandin FP analogs are leading the therapeutic intervention for glaucoma, new target classes also are being identified with new lead

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