All Photos(1)
Synonym(s):
[(1S)-2,2-Difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-methanone tosylate salt
Empirical Formula (Hill Notation):
C18H21F2N7O · C7H8O3S
CAS Number:
Molecular Weight:
561.60
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
SMILES string
FC1(F)C[C@H]1C(N2[C@H]3CN(C4=CC=NC(NC5=CN(C)N=C5)=N4)C[C@@H]2CC3)=O.CC6=CC=C(S(=O)(O)=O)C=C6
Application
PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.
Biochem/physiol Actions
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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308 Bone marrow/cord blood transplantation (BMCBT) ameliorates symptoms in some, but not all, subtypes of severe generalized junctional epidermolysis bullosa (JEB).
Hook K, et al.
The Journal of Investigative Dermatology, 137(5), S52-S52 (2017)
Andrew Fensome et al.
Journal of medicinal chemistry, 61(19), 8597-8612 (2018-08-17)
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain cytokines, interleukin (IL)-6, and type-I interferon (IFN) family
Christopher R Donnelly et al.
Nature, 591(7849), 275-280 (2021-01-15)
The innate immune regulator STING is a critical sensor of self- and pathogen-derived DNA. DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other cytokines, which promote immune-cell-mediated eradication of pathogens and neoplastic cells1,2. STING is
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