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PZ0213

Sigma-Aldrich

PF-04418948

≥98% (HPLC)

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Synonym(s):
1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid
Empirical Formula (Hill Notation):
C23H20FNO5
CAS Number:
1078166-57-0
Molecular Weight:
409.41
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

InChI

1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)

InChI key

LWJGMYMNSNVCEM-UHFFFAOYSA-N

Application

PF-04418948 has been used in TG (trigeminal ganglion) explant culture.

Biochem/physiol Actions

PF-04418948 is a PGE2 Receptor (EP2) specific antagonist (IC50 = 16 nM) with greater than 2000-fold selectivity over other EP subtypes. PF-04418948 inhibits EP2 activity in smooth muscle preps from human, dog and mouse.
PF-04418948 represses the formation of colorectal tumor.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats.
Zhang P, et al.
Journal of Neuroinflammation, 15(1), 117-117 (2018)
Prostaglandin E 2-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment.
Aoki T and Narumiya S
Inflammation and regeneration, 37(1), 4-4 (2017)
Naoko Komura et al.
Cancer immunology, immunotherapy : CII, 69(12), 2477-2499 (2020-06-21)
The aim of this study was to investigate the role of myeloid-derived suppressor cells (MDSC) in the induction of cancer stem-like cells (CSC) and programmed death ligand 1 (PD-L1) expression in ovarian cancer. CSC were defined as tumor cells expressing
Eva Mangelsen et al.
Cells, 9(5) (2020-05-23)
Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman's space. Elevated Prostaglandin E2 (PGE2) synthesis and upregulated cyclooxygenase 2 (Cox2) are associated with podocyte

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