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Merck
CN

PZ0171

CP-100356 monohydrochloride

>98% (HPLC), powder, MDR1 (P-Gp) inhibitor

Synonym(s):

4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C31H36N4O6 · HCl
CAS Number:
142715-48-8
Molecular Weight:
597.10
UNSPSC Code:
12161501
PubChem Substance ID:
329823745
NACRES:
NA.77
MDL number:
MFCD00911858

Key Documents

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Product Name

CP-100356 monohydrochloride, >98% (HPLC)

SMILES string

Cl.COc1ccc(CCNc2nc(N3CCc4cc(OC)c(OC)cc4C3)c5cc(OC)c(OC)cc5n2)cc1OC

InChI

1S/C31H36N4O6.ClH/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35;/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34);1H

InChI key

WWCHXVYTCMPAMV-UHFFFAOYSA-N

assay

>98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter.
CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000508967
0000508967
0000350765
0000350765
0000189188

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Sally Park et al.
Small GTPases, 12(2), 147-160 (2019-10-12)
Rho proteins are signalling molecules that control cellular dynamics, movement and morphological changes. They are activated by Rho guanine-nucleotide exchange factors (Rho GEFs) that transduce upstream signals into Rho-mediated activation of downstream processes. Fgd5 is a Rho GEF involved in

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