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PZ0148

Sigma-Aldrich

CP-802079 hydrochloride hydrate

≥98% (HPLC)

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Synonym(s):
({3-(4-Chlorophenyl)-3-[4-(thiazole-carbonyl)-phenoxy]-propyl}-methyl-amino)-acetic acid hydrochloride hydrate, N-[3-(4-Chlorophenyl)-3-[4-(2-thiazolylcarbonyl)phenoxy]propyl]-N-methyl-glycine hydrochloride hydrate
Empirical Formula (Hill Notation):
C22H21ClN2O4S · xHCl · yH2O
CAS Number:
736175-49-8
Molecular Weight:
444.93 (anhydrous free base basis)
MDL number:
MFCD18452850
UNSPSC Code:
12352200
PubChem Substance ID:
329823733
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

very light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.CN(CCC(Oc1ccc(cc1)C(=O)c2nccs2)c3ccc(Cl)cc3)CC(O)=O

InChI

1S/C22H21ClN2O4S.ClH.H2O/c1-25(14-20(26)27)12-10-19(15-2-6-17(23)7-3-15)29-18-8-4-16(5-9-18)21(28)22-24-11-13-30-22;;/h2-9,11,13,19H,10,12,14H2,1H3,(H,26,27);1H;1H2

InChI key

CVQXAUBKPDYXHF-UHFFFAOYSA-N

Biochem/physiol Actions

CP-802079 is a potent and selective glycine transporter type 1 (GlyT1) antagonist. Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, they can augment NMDAR currents and NMDAR-mediated functions. CP-802,079 significantly increases the amplitude of the NMDAR currents and LTP.

Features and Benefits

This compound is featured on the Glycine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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