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Merck
CN

PZ0123

Avridine

≥97% (HPLC)

Synonym(s):

CP 20961, N,N-Dioctadecyl-N′,N′-bis(2-hydroxyethyl)-1,3-diaminopropane, N,N-Dioctadecyl-N′,N′-bis(2-hydroxyethyl)propanediamine

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About This Item

Empirical Formula (Hill Notation):
C43H90N2O2
CAS Number:
35607-20-6
Molecular Weight:
667.19
NACRES:
NA.77
PubChem Substance ID:
329823713
UNSPSC Code:
51111800
MDL number:
MFCD00673242

Key Documents

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InChI key

WXNRAKRZUCLRBP-UHFFFAOYSA-N

SMILES string

CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CCCN(CCO)CCO

InChI

1S/C43H90N2O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-44(38-35-39-45(40-42-46)41-43-47)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h46-47H,3-43H2,1-2H3

assay

≥97% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥5 mg/mL (with warming to 60 °C for 5 minutes)

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

Avridine is a potent synthetic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
040M4708

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L Overgaard et al.
The Journal of bone and joint surgery. British volume, 80(5), 888-893 (1998-10-13)
Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative
A E Kingston et al.
Clinical and experimental immunology, 103(1), 77-82 (1996-01-01)
The effects of a mycobacterial 71-kD hsp antigen have been investigated for its ability to modulate arthritis in rats. Subcutaneous injection (base of tail) of increasing amounts of hsp71 from Mycobacterium tuberculosis (MTB) produced dose-dependent differential inhibitory effects on induction
Genetic factors regulating experimental arthritis in mice and rats.
R L Wilder et al.
Current directions in autoimmunity, 1, 121-165 (2002-01-17)
D M Pérez Filgueira et al.
Vaccine, 17(4), 345-352 (1999-02-13)
Different immunomodulators have been previously tested in our laboratory as enhancers of the specific immune response to FMDV vaccines in a murine model [2-4]. Here, we present results of two of these immunomodulators, a water-soluble fraction of the cell wall
C Vingsbo et al.
Clinical and experimental immunology, 99(3), 359-363 (1995-03-01)
Avridine is a potent synthetic adjuvant that can induce arthritis is most rat strains. The clinical appearance and histopathology of avridine-induced arthritis show great similarity to other arthritis models such as collagen-induced arthritis. In LEW and DA rats the avridine-induced
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