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PZ0123

Sigma-Aldrich

Avridine

≥97% (HPLC)

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Synonym(s):
CP 20961, N,N-Dioctadecyl-N′,N′-bis(2-hydroxyethyl)-1,3-diaminopropane, N,N-Dioctadecyl-N′,N′-bis(2-hydroxyethyl)propanediamine
Empirical Formula (Hill Notation):
C43H90N2O2
CAS Number:
35607-20-6
Molecular Weight:
667.19
MDL number:
MFCD00673242
UNSPSC Code:
51111800
PubChem Substance ID:
329823713
NACRES:
NA.77

Quality Level

100

Assay

≥97% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥5 mg/mL (with warming to 60 °C for 5 minutes)

storage temp.

room temp

SMILES string

CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CCCN(CCO)CCO

InChI

1S/C43H90N2O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-44(38-35-39-45(40-42-46)41-43-47)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h46-47H,3-43H2,1-2H3

InChI key

WXNRAKRZUCLRBP-UHFFFAOYSA-N

Biochem/physiol Actions

Avridine is a potent synthetic adjuvant that can induce arthritis in most rat strains; immunomodulator and interferon-inducing.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Comparative susceptibility of DA, LEW, and LEW.1AV1 rats to arthritis induced with different arthritogens: mineral oil, mycobacteria, muramyl dipeptide, avridine and rat collagen type II.
J C Lorentzen et al.
Transplantation proceedings, 29(3), 1692-1693 (1997-05-01)
Administration of intraliposomal CP20961 to mice activates peritoneal macrophages and augments serum antibody response to Toxoplasma gondii.
D Mack et al.
The Journal of eukaryotic microbiology, 41(5), 12S-12S (1994-09-01)
Chenguang Zhou et al.
Therapeutic delivery, 3(6), 715-723 (2012-07-31)
Lack of safe and efficient delivery of siRNA remains the greatest hurdle for the therapeutic application of siRNA. This article reports synthesis and evaluation of novel lipoidal amine-based nanocarrier (LANC) formulations for siRNA delivery. Physicochemical properties were analyzed for LANC
L Overgaard et al.
The Journal of bone and joint surgery. British volume, 80(5), 888-893 (1998-10-13)
Little is known about the tissue reactions to various implant materials which coincide with an inflammatory reaction. We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion. Quantitative
A E Kingston et al.
Clinical and experimental immunology, 103(1), 77-82 (1996-01-01)
The effects of a mycobacterial 71-kD hsp antigen have been investigated for its ability to modulate arthritis in rats. Subcutaneous injection (base of tail) of increasing amounts of hsp71 from Mycobacterium tuberculosis (MTB) produced dose-dependent differential inhibitory effects on induction
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