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PZ0113

Sigma-Aldrich

PD173952

≥98% (HPLC)

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Synonym(s):
6-(2,6-Dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, PD-173952
Empirical Formula (Hill Notation):
C24H21Cl2N5O2
CAS Number:
305820-75-1
Molecular Weight:
482.36
MDL number:
MFCD16875428
UNSPSC Code:
12352200
PubChem Substance ID:
329823705
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

yellow to green

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CN1C(=O)C(=Cc2cnc(Nc3ccc(cc3)N4CCOCC4)nc12)c5c(Cl)cccc5Cl

InChI

1S/C24H21Cl2N5O2/c1-30-22-15(13-18(23(30)32)21-19(25)3-2-4-20(21)26)14-27-24(29-22)28-16-5-7-17(8-6-16)31-9-11-33-12-10-31/h2-8,13-14H,9-12H2,1H3,(H,27,28,29)

InChI key

XZEJMVDCQZRHLN-UHFFFAOYSA-N

Biochem/physiol Actions

PD173952 is a Src family kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Alexander Rohe et al.
Bioorganic & medicinal chemistry, 23(15), 4936-4942 (2015-06-11)
Myt1 kinase is a member of the Wee-kinase family involved in G2/M checkpoint regulation of the cell cycle. So far, no peptide substrate suitable for activity-based screening has been reported, hampering systematic development of Myt1 kinase inhibitors. Myt1 inhibitors had

Articles

Src Family Kinases Overview

Src is the original member of a group of non-receptor protein-tyrosine kinases termed the Src family kinases (SFKs). Learn about the SFKs that, in humans, consist of eight members, a small group of atypical members, and two related kinases.

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