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PZ0106

Sigma-Aldrich

SC-236

≥98% (HPLC)

Synonym(s):

4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide, SC-58236

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100 μG
CN¥4,985.59

CN¥4,985.59

Estimated to ship onApril 15, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZMS1017
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100 μG
CN¥4,985.59

About This Item

Empirical Formula (Hill Notation):
C16H11ClF3N3O2S
CAS Number:
170569-86-5
Molecular Weight:
401.79
MDL number:
MFCD00941297
UNSPSC Code:
12352202
PubChem Substance ID:
329823698
NACRES:
NA.77

CN¥4,985.59

Estimated to ship onApril 15, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZMS1017
Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

NS(=O)(=O)c1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F

InChI

1S/C16H11ClF3N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)

InChI key

NSQNZEUFHPTJME-UHFFFAOYSA-N

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antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

ascites fluid

antibody form

purified antibody

biological source

mouse

biological source

mouse

biological source

mouse

biological source

rat

shipped in

ambient

shipped in

ambient

shipped in

wet ice

shipped in

wet ice

technique(s)

ChIP: suitable, dot blot: suitable, immunoprecipitation (IP): suitable, affinity binding assay: suitable, immunocytochemistry: suitable

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

ChIP: suitable (ChIP-seq), ELISA: suitable, immunocytochemistry: suitable, western blot: suitable

isotype

IgG2aκ

isotype

IgG1

isotype

IgG1

isotype

IgG2bκ

Application

SC-236 has been used as a COX-2 inhibitor to study its effects on the mechano-reflex in rats.[1]

Biochem/physiol Actions

SC-236 exhibits anti-tumor activity in gastric cancer cells by modulating activator protein-1 (AP-1) expression and by blocking the anchorage-independent cell growth.[2] It also exhibits a protective effect against cartilage damage by minimizing the inflammation and pain in osteoarthritis. It is also reported to treat allergic inflammation.[3]
SC-236 is a cyclooxygenase-2 (COX-2) inhibitor.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000156425
    0000066315
    0000066314
    0000022410

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