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Merck
CN

PZ0018

Bazedoxifene acetate

≥98% (HPLC), Selective estrogen receptor modulator (SERM), powder

Synonym(s):

1-[4-(2-Azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetate, TSE-424, WAY-140424, WAY-TSE-424

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About This Item

Empirical Formula (Hill Notation):
C30H34N2O3 · C2H4O2
CAS Number:
198481-33-3
Molecular Weight:
530.65
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Product Name

Bazedoxifene acetate, ≥98% (HPLC)

SMILES string

[N+H]5(CCCCCC5)CCOc1ccc(cc1)C[n]2c3c(c(c2c4ccc(cc4)O)C)cc(cc3)O.[O-]C(=O)C

InChI

1S/C30H34N2O3.C2H4O2/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31;1-2(3)4/h6-15,20,33-34H,2-5,16-19,21H2,1H3;1H3,(H,3,4)

InChI key

OMZAMQFQZMUNTP-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Related Categories

Application

Bazedoxifene acetate has been used to study its efficacy in inhibiting the interleukin-6 (IL-6)/IL-6R/glycoprotein 130 pathway and its effects on medulloblastoma cells.

Biochem/physiol Actions

Bazedoxifene is a third generation nonsteroidal selective estrogen receptor modulator (SERM), used clinically to treat postmenopausal osteoporosis. Bazedoxifene binds to estrogen receptor-α with IC50 = 26 nM, similar to that of raloxifene, but lower affinity than 17-β estradiol. Bazedoxifene did not stimulate proliferation of MCF-7 cells, instead inhibited 17β -estradiol-induced proliferation with IC50 = 0.19 nM, exhibiting a desirable profile of agonist/antagonist activity.
Bazedoxifene is a third generation nonsteroidal selective estrogen receptor modulator (SERM).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000508961
0000508961
0000344486
0000344486
0000201982

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Blanca D López-Ayllón et al.
Frontiers in immunology, 14, 1220306-1220306 (2023-08-07)
SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. In this study, transcriptomics analysis revealed that both WNT5A and IL11 were significantly up-regulated in A549
Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells
Xiang Chen
International Journal of Oncology (2018)
Yanan Chen et al.
eLife, 10 (2021-03-24)
The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhancing the ISR can improve remyelination in an inflammatory environment.
Adam T Szafran et al.
iScience, 25(10), 105200-105200 (2022-10-15)
The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling. We characterize two new PRL-HeLa cell models expressing either inducible C-terminal (iGFP-ER) or
Xiang Chen et al.
International journal of oncology, 52(2), 571-578 (2017-12-06)
Elevated levels of the pro-inflammatory cytokine interleukin-6 (IL‑6) have tumor-promoting activity and are associated with poor survival outcomes in many cancers. Additionally, the IL‑6/GP130/STAT3 axis has been widely studied due to its pivotal role in tumor development and maintenance in
View All Related Papers

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