PRS3627
Anti-LAMP-2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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Anti-Lysosomal-associated membrane protein 2
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Lamp2(16784)
General description
Lamp2 (lysosome-associated membrane protein gene)is located in the lysosomal lumen and lysosomal membrane. However upon chronic acidosis in the tumour microenvironment, it is found to be present in the plasma membrane.
Immunogen
a 17 amino acid peptide from near the center of human LAMP-2.
Application
Anti-LAMP-2 antibody has been used in immunofluorescence and western blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Biochem/physiol Actions
LAMP2 (lysosome-associated membrane protein gene) preserves lysosomal membranes from acid proteolysis. It serves as an acidity biomarker in spheroids and xenografts. It also has some role in maturation of autophagic vacuoles and cell-cell or cell-extracellular matrix adhesion. Reduction of LAMP2 (lysosome-associated membrane protein gene) can increase acidosis-mediated toxicity. Mutation in LAMP2 can cause cardiomyopathy in young patients.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3627.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
related product
Product No.
Description
Pricing
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
Nature Communications, 6:8752 (2015)
Effects of white light-emitting diode (LED) exposure on retinal pigment epithelium in vivo
Journal of Cellular and Molecular Medicine (2017)
Unique properties of lamp2a compared to other lamp2 isoforms
Journal of Cell Science, 113 Pt 24, 4441-4450 (2000)
Journal of cellular and molecular medicine, 21(12), 3453-3466 (2017-07-01)
Ageing and alteration of the functions of the retinal pigment epithelium (RPE) are at the origin of lost of vision seen in age-related macular degeneration (AMD). The RPE is known to be vulnerable to high-energy blue light. The white light-emitting
Characterization of stress response in human retinal epithelial cells.
Journal of Cellular and Molecular Medicine, 17(1), 103-115 (2013)
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