PRS3363
Anti-ST2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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Anti-Interleukin 1 receptor-like 1
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Il1rl1(17082)
General description
ST2 (suppression of tumorigenicity) belongs to the IL-1 family of cytokines. It is also known as IL-33 (interleukin 33) and IL1RL1 (interleukin 1 receptor like 1). It is expressed in macrophages and various inflammatory cells like T helper 2 (Th2), mast cells, basophils and eosinophils. It is mapped to chromosome 2q12.
Immunogen
a synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2. This peptide is common to all three known ST2 isoforms.
Application
Anti-ST2 has been used in immunohistochemistry, western blottingand immunofluorescence staining.
Biochem/physiol Actions
ST2 (suppression of tumorigenicity) participates in pathophysiology of several diseases like asthma, arthritis, obesity and atherosclerosis. It works as a mitogen in eosinophils, fibrocytes, endothelial cells. It helps in the migration of Th2 lymphocytes, fibrocytes and endothelial cells, and disturbs the incursion and metastasis of breast tumor.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3363.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
related product
Product No.
Description
Pricing
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Molecular human reproduction, 20(4), 358-372 (2013-12-18)
Interleukin (IL)-33, a newly described member of the IL-1 family, has been reported to facilitate primary tumor progression and metastatic dissemination. However, its biological function on decidual stromal cells (DSCs) remains unclear. In this study, we tested the hypothesis whether
Gut, 62(12), 1714-1723 (2012-11-23)
Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing and permeability in
The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
Oncoimmunology, 5(1) (2015)
ST2L Transmembrane Receptor Expression: An Immunochemical Study on Endarterectomy Samples
PLoS ONE, 11(5) (2016)
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
Gut, 62(12), 1714-1723 (2013)
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