PLA0303
Goat anti-53BP1 Antibody, Affinity Purified
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1, 53BP1, TDRD30, TP53, p202, p53-binding protein 1, p53BP1, tumor protein 53-binding protein, tumor protein p53-binding protein
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biological source
goat
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
grade
Powered by Bethyl Laboratories, Inc.
species reactivity
human
concentration
1 mg/mL
technique(s)
immunohistochemistry: 1:500-1:2,000
immunoprecipitation (IP): 2- 10 μg/mg
accession no.
NP_005648.1
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
goat ... 53BP1(7158)
General description
p53 binding protein 1 (53BP1), also known as, tumor protein p53 binding protein 1, is homologous to the DNA damage checkpoint protein Rad9p of Saccharomyces cerevisiae. In the human chromosome, 53BP1 is localized on 15q15.3.
Immunogen
The epitope recognized by PLA0303 maps to a region between residue 350 and 400 of human Tumor Protein p53 Binding Protein, 1 using the numbering given in entry NP_005648.1 (GeneID 7158).
Biochem/physiol Actions
p53 binding protein 1 (53BP1) is a transcriptional activator of tumour suppressor protein p53. 53BP1 senses the double strand DNA breaks induced by ionising radiations and chemicals and involved in the DNA repair pathway. 53BP1 is a downstream target of ataxia telangiectasia mutated (ATM) phosphorylation. 53BP1 binds to histone 3 lysine 79 methylated residues (H3K79) or dimethylated histone 4 lysine 20 (H4K20me2) via the tandem tudor domain, which enables its interaction with the double strand DNA breaks.
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
The Journal of Cell Biology, 151(7), 1381-1390 (2000)
53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma
Cancer Research, canres-ca0045 (2012)
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
The Journal of Cell Biology, 153(3), 613-620 (2001)
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Nature, 432(7015), 406-411 (2004)
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
Cell, 127(7), 1361-1373 (2006)
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