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PLA0126

Sigma-Aldrich

Rabbit anti-Phospho 53BP1 (S25) Antibody, Affinity Purified

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Synonym(s):
1, 53BP1, TDRD30, TP53, p202, p53-binding protein 1, p53BP1, tumor protein 53-binding protein, tumor protein p53-binding protein
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

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species reactivity

mouse, human

technique(s)

immunohistochemistry: 1:1,000- 1:5,000
immunoprecipitation (IP): 1- 4 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_005648.1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

phosphorylation (pSer25 )

Gene Information

human ... TP53BP1(7158)

Immunogen

Immunogen for PLA0126 was a phosphorylated synthetic peptide, which represented a portion of human p53 Binding Protein 1 (GeneID 7158) around serine 25 according to the numbering given in entry NP_005648.1.

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Devon Lundine et al.
Molecular cancer research : MCR, 20(12), 1799-1810 (2022-09-09)
The TP53 gene is mutated in 80% of triple-negative breast cancers. Cells that harbor the hot-spot p53 gene mutation R273H produce an oncogenic mutant p53 (mtp53) that enhances cell proliferative and metastatic properties. The enhanced activities of mtp53 are collectively

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