PLA0100
Rabbit anti-MLL1 Antibody, Affinity Purified
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Synonym(s):
ALL-1, CDK6/MLL fusion protein, CXXC-type zinc finger protein 7, CXXC7, HRX, HTRX1, MLL, MLL-AF4 der(11) fusion protein, MLL-AF9, MLL/ENL fusion protein, MLL/GAS7, MLL/GAS7 fusion protein, MLL/GMPS fusion protein, MLL/hCDCrel fusion protein, MLL1, MLL1A, Myeloid/lymphoid or mixed-lineage leukemia, TET1-MLL, TRX1, WDSTS, lysine (K)-specific methyltransferase 2A, lysine N-methyltransferase 2A, mixed lineage leukemia 1, rearranged MLL protein, trithorax-like protein, zinc finger protein HRX
UNSPSC Code:
12352203
NACRES:
NA.43
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
grade
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species reactivity
human
technique(s)
ChIP: 1- 5 μg
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000-1:10,000
accession no.
Q03164
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
rabbit ... MLL1(4297)
General description
MLL1 (mixed-lineage leukemia) gene is also referred as KMT2A (lysine methyltransferase 2A) and is located on human chromosome locus 11q23.3.
Immunogen
The epitope recognized by PLA0100 maps to a region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).
Biochem/physiol Actions
MLL1 (mixed-lineage leukemia) is a histone methyltransferase and has a role in embryogenesis and hematopoiesis. MLL1 is a transcriptional co-activator and regulates epigenetic gene expression through chromatin modification. MLL1 is associated with NF-κB (nuclear factor kappa B) pathway- induced brain tumor proliferation. On the other hand, MLL1 is known to prevent metastasis and invasion in cervical cancer.
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway.
Zhang C, et al.
Cell Death & Disease, 8(7), e2940-e2940 (2017)
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability.
Grey W, et al.
Biochimica et Biophysica Acta, 1865(1), 105-116 (2018)
Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.
Tarlock K, et al.
Clinical Cancer Research, 23(14), 3649-3656 (2017)
Yan Jin et al.
PLoS biology, 19(6), e3001297-e3001297 (2021-06-11)
Recent studies have shown that long noncoding RNAs (lncRNAs) are critical regulators in the central nervous system (CNS). However, their roles in the cerebellum are currently unclear. In this work, we identified the isoform 204 of lncRNA Gm2694 (designated as
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