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Safety Information

P9809

Sigma-Aldrich

Pancreastatin Fragment 37-52 human

≥97% (HPLC)

Synonym(s):

Chromograinin A fragment 286-301

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About This Item

Empirical Formula (Hill Notation):
C78H123N21O27S
CAS Number:
133605-57-9
Molecular Weight:
1819.00
MDL number:
MFCD00080083
UNSPSC Code:
12352202
PubChem Substance ID:
24898924

Assay

≥97% (HPLC)

form

powder

UniProt accession no.

P10645

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(N)CCC(O)=O)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O

InChI

1S/C78H123N21O27S/c1-38(2)34-51(73(122)96-52(35-42-14-10-9-11-15-42)74(123)90-44(16-12-31-84-78(82)83)66(115)85-36-55(81)101)88-56(102)37-86-67(116)45(19-24-54(80)100)95-75(124)53-17-13-32-99(53)77(126)63(40(5)6)98-76(125)62(39(3)4)97-64(113)41(7)87-68(117)50(30-33-127-8)94-72(121)49(23-29-61(111)112)93-71(120)48(22-28-60(109)110)92-70(119)47(21-27-59(107)108)91-69(118)46(20-26-58(105)106)89-65(114)43(79)18-25-57(103)104/h9-11,14-15,38-41,43-53,62-63H,12-13,16-37,79H2,1-8H3,(H2,80,100)(H2,81,101)(H,85,115)(H,86,116)(H,87,117)(H,88,102)(H,89,114)(H,90,123)(H,91,118)(H,92,119)(H,93,120)(H,94,121)(H,95,124)(H,96,122)(H,97,113)(H,98,125)(H,103,104)(H,105,106)(H,107,108)(H,109,110)(H,111,112)(H4,82,83,84)

InChI key

RLWQXZBLTNWVHR-UHFFFAOYSA-N

Gene Information

human ... CHGA(1113)

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
031M1592V
117K1221
103K1255
073K0564

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O Nagakawa et al.
Cancer letters, 147(1-2), 207-213 (2000-02-05)
We investigated the effect of chromogranin A (pancreastatin) fragment on the invasion of PC-3, DU-145 and LNCaP prostate cancer cells through a reconstituted basement membrane (Matrigel) using a Transwell cell culture chamber assay. Chromogranin A fragment increased the invasive capacity
Osamu Nagakawa et al.
Urology, 62(3), 553-558 (2003-08-30)
To investigate the effect of various chromogranin A (CgA) fragments on the invasion, haptotactic migration, and growth of prostate cancer cells. We investigated the effect of five kinds of CgA fragments (79-115, 286-301, 324-341, 344-374, and 356-374) on the invasion
K B Helle et al.
Cellular and molecular life sciences : CMLS, 64(22), 2863-2886 (2007-08-25)
Chromogranin A (CgA) belongs to the granin family of uniquely acidic secretory proteins co-stored and co-secreted with other hormones and peptides in elements of the diffuse neuroendocrine system. The granins arise from different genes and are characterized by numerous sites
Víctor Sánchez-Margalet et al.
Regulatory peptides, 161(1-3), 8-14 (2010-02-27)
Pancreastatin is one of the regulatory peptides derived from intracellular and/or extracellular processing of chromogranin A, the soluble acidic protein present in the secretory granules of the neuroendocrine system. While the intracellular functions of chromogranin A include formation and maturation

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