P9489
Anti-p35 (Cdk5 Regulator) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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Anti-CDK5P35, Anti-CDK5R, Anti-NCK5A, Anti-p23, Anti-p25, Anti-p35, Anti-p35nck5a
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 35 kDa
species reactivity
human, rat
technique(s)
microarray: suitable
western blot: 1:1,000 using a rat brain extract (cytosolic fraction)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CDK5R1(8851)
rat ... Cdk5r1(116671)
General description
Cell division protein kinase 5 (Cdk5) is a serine/threonine kinase and shares homology to other Cdks. It belongs to cdk family.
Immunogen
synthetic peptide corresponding to the C-terminus of p35 (Cdk5R), (human, amino acids 192-209).
Application
Anti-p35 (Cdk5 Regulator) antibody produced in rabbit has been used in western blotting and immunohistochemistry.
Biochem/physiol Actions
Cell division protein kinase 5 (Cdk5) kinase activity can be detected mainly in postmitotic neurons in the central nervous system (CNS). Cdk5/p35 activity is required in the mature CNS. Cdk5 phosphorylates dopamine and cyclic adenosine 3′,5′-monophosphate-regulated phosphoprotein of 32 kDa (DARPP-32) and Syntaxin-binding protein 1 (Munc18), which in turn affects synaptic vesicle endocytosis. Deregulation of Cdk5 activity contributes to the pathogenesis of neurodegenerative diseases such as Alzheimer′s disease (AD). It mediates neuronal migration during cortical development. Cdk5-/- mice exhibit embryonic lethality associated with disruption of the cortical laminar structures in the cerebral cortex, olfactory bulb, hippocampus, and cerebellar cortex. Mice lacking p35 display defects in cortical lamination and fasciculation of axonal fibers. In developing mice brain, Cdk5/p35 interacts with Reelin/Dab1 and positions of cortical neurons.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Find documentation for the products that you have recently purchased in the Document Library.
Deregulated Cdk5 activity is involved in inducing Alzheimer?s disease
Archives of Medical Research, 43(8), 655-662 (2012)
Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase
Current Biology, 10(7), 363-372 (2000)
Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects
Proceedings of the National Academy of Sciences of the USA, 101(16), 6249-6254 (2004)
NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease
Aging Cell, 15(4), 661-672 (2016)
Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca2+-dependent exocytosis
The Journal of Biological Chemistry, 279(28), 29534-29541 (2004)
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