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P9180

Sigma-Aldrich

Procaterol hydrochloride

Synonym(s):

erythro-8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]-2(1H)-quinolinone

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About This Item

Empirical Formula (Hill Notation):
C16H22N2O3 · HCl
CAS Number:
62929-91-3
Molecular Weight:
326.82
EC Number:
263-763-0
MDL number:
MFCD04221378
UNSPSC Code:
12352202
PubChem Substance ID:
24899017
NACRES:
NA.77

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

Cl.CC[C@H](NC(C)C)[C@H](O)c1ccc(O)c2NC(=O)C=Cc12

InChI

1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1

InChI key

AEQDBKHAAWUCMT-CVHDTDHSSA-N

General description

Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells.

Biochem/physiol Actions

β2-adrenoceptor agonist; bronchodilator.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Immune System Diseases: New Insights for the Healthcare Professional (2012)
Y Yamazaki et al.
British journal of pharmacology, 124(3), 593-599 (1998-07-01)
1. The beta-adrenoceptor (beta-AR) subtypes mediating relaxation of the rabbit, rat and canine detrusors were subjected to functional investigation using selective beta-AR agonists and antagonists. 2. In all three species, isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of
Nobuyo Komatani-Tamiya et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 29(3-4), 511-522 (2012-04-18)
The beating cilia play a key role in lung mucociliary transport. The ciliary beating frequency (CBF) and ciliary bend amplitude (CBA) of isolated mouse bronchiolar ciliary cells were measured using a light microscope equipped with a high-speed camera (500 Hz).
Ching-Hua Huang et al.
Pediatric pulmonology, 45(10), 977-984 (2010-07-31)
Procaterol is a β2-adrenoceptor agonist used as a bronchodilator for the treatment of asthma; it also possesses an anti-inflammatory property. As chemokines play a pivotal role in inflammation and the pathogenesis of asthma, we investigated the effects of procaterol on
Masahiro Satake et al.
Arzneimittel-Forschung, 61(1), 8-13 (2011-03-02)
The purpose of this study was to evaluate the inhibitory effect of procaterol (procaterol hydrochloride, CAS 62929-91-3) on exercise dynamic lung hyperinflation during the 6-min walk test (6MWT) in stable chronic obstructive disease (COPD) patients. Fourteen patients with stable COPD
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