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P9158

Sigma-Aldrich

Pyridoxamine dihydrochloride

BioReagent, suitable for cell culture

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Synonym(s):
4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride
Empirical Formula (Hill Notation):
C8H12N2O2 · 2HCl
CAS Number:
524-36-7
Molecular Weight:
241.11
Beilstein:
3632748
EC Number:
208-357-6
MDL number:
MFCD00012808
UNSPSC Code:
12352205
PubChem Substance ID:
24899015
NACRES:
NA.75

biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

Assay

≥98%

form

powder

mol wt

Mw 241.11 g/mol

technique(s)

cell culture | mammalian: suitable

color

white to off-white

mp

224-226 °C (dec.) (lit.)

solubility

water: soluble 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].Cc1ncc(CO)c(CN)c1O

InChI

1S/C8H12N2O2.2ClH/c1-5-8(12)7(2-9)6(4-11)3-10-5;;/h3,11-12H,2,4,9H2,1H3;2*1H

InChI key

HNWCOANXZNKMLR-UHFFFAOYSA-N

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Application

Use in mammalian cell culture as an alternative to pyridoxine or pyridoxal. Vitamin B6 is a required component of cell culture media. Historically, media have been supplemented with vitamin B6 in the aldehyde form, pyridoxal. While this is a biologically active form of vitamin B6, it is unstable in liquid media. When cells are able to utilize either pyridoxine and/or pyridoxamine, they are preferred supplement versus pyridoxal. A number of classical media are now offered with a choice between pyridoxal and pyridoxine as the vitamin A source.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

Vitamin B6's impact on serum-free cell culture systems is explored for protein manufacturing.

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