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P8953

Sigma-Aldrich

Platelet-Derived Growth Factor from porcine platelets

PDGF, lyophilized powder, suitable for cell culture

Synonym(s):

PDGF

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About This Item

MDL number:
MFCD00166903
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

Porcine

Quality Level

200

Assay

≥97% (SDS-PAGE and N-terminal analysis)

form

lyophilized powder

potency

39.00 ng/mL EC50

quality

endotoxin tested

mol wt

glycoprotein 38 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

color

white

UniProt accession no.

P20034

storage temp.

−20°C

Gene Information

pig ... PDGFB(100626465)

Related Categories

Application

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

Biochem/physiol Actions

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

Physical form

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

Analysis Note

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Articles

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

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