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Key Documents

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Safety Information

P8783

Sigma-Aldrich

Progesterone

powder, BioReagent, suitable for cell culture

Synonym(s):

4-Pregnene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C21H30O2
CAS Number:
57-83-0
Molecular Weight:
314.46
Beilstein:
1915950
EC Number:
200-350-6
MDL number:
MFCD00003658
UNSPSC Code:
12352209
PubChem Substance ID:
24898978
NACRES:
NA.77
biological source:
synthetic (organic)
form:
powder
Pricing and availability is not currently available.

biological source

synthetic (organic)

Quality Level

200

description

synthesized from materials derived from plant source

product line

BioReagent

Assay

≥99%

form

powder

potency

0.1-20 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

128-132 °C (lit.)

solubility

absolute ethanol: 1 mg/mL

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EZFITSAM3EZFITSAM6EZFITMHTA3
EZ-Fit® Manifold 1-place manifold, for use with EZ-Fit® Filtration Unit, 316L stainless steel

EZFITSAM1

EZ-Fit® Manifold

EZ-Fit® Manifold 3-place manifold, for use with EZ-Fit® Filtration Unit, stainless steel

EZFITSAM3

EZ-Fit® Manifold

EZ-Fit® Manifold 6-place manifold, for use with EZ-Fit® Filtration Unit, 316L stainless steel

EZFITSAM6

EZ-Fit® Manifold

EZ-Fit® Manifold Filtration Head for use with EZ-Fit® Filtration Manifold, For use with EZ-Fit® filtration units, 3 units, pkg of 3 unit

EZFITMHTA3

EZ-Fit® Manifold Filtration Head

application(s)

pharmaceutical

application(s)

bioburden testing
food and beverages
industrial hygiene
industrial qc
pharmaceutical
water monitoring

application(s)

pharmaceutical

application(s)

-

packaging

pkg of 1 unit

packaging

pkg of 1 unit

packaging

pkg of 1 unit

packaging

pkg of 3 unit

material

316L stainless steel

material

stainless steel

material

316L stainless steel

material

316L stainless steel

sterilization compatibility

autoclavable compatible

sterilization compatibility

autoclavable compatible

sterilization compatibility

autoclavable compatible

sterilization compatibility

autoclavable compatible

manufacturer/tradename

EZ-Fit®

manufacturer/tradename

EZ-Fit®

manufacturer/tradename

EZ-Fit®

manufacturer/tradename

EZ-Fit®

General description

Progesterone is a steroid hormone secreted by the ovaries.[1]

Application

Progesterone has been used:
  • as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture[2]
  • to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model[3]
  • as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells[4]

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.
Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy.[5] It is known to prevent preterm delivery, when administered intramuscularly.[6] Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.[7]

Other Notes

Steroid hormone produced by the corpus luteum.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H351,H360FD,H362

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000429442
0000429441
0000429434
0000429434
0000429442

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Efficacy of progesterone following a moderate unilateral cortical contusion injury
Gilmer LK, et al.
Journal of Neurotrauma, 25(6), 593-602 (2008)
Peroxisome proliferator-activated receptor-? activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents
A.K.G.Kadegowda, et al.
Journal of Dairy Science, 92, 276-4289 (2009)
Clinical Reproductive Medicine and Surgery, 84(7), 17-17 (2007)
Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to uterine dysfunction
Dhakal P, et al.
Endocrinology, 156(10), 3791-3803 (2015)
Internalization of coxsackievirus A9 is mediated by beta2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin
Heikkila O, et al.
Journal of Virology, 84(7), 3666-3681 (2010)
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