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Merck
CN

P8638

Poly-DL-ornithine hydrobromide

suitable for cell culture, Mol wt 3,000-15,000

Synonym(s):

DL-Ornithine homopolymer hydrobromide

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About This Item

CAS Number:
82682-33-5
UNSPSC Code:
12352209
PubChem Substance ID:
24898960
NACRES:
NA.26
MDL number:
MFCD00166384

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Product Name

Poly-DL-ornithine hydrobromide, mol wt 3,000-15,000

InChI

1S/C5H12N2O2.BrH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H

InChI key

GWRQMKDBBHFVIZ-UHFFFAOYSA-N

SMILES string

Br.NCCCC(N)C(O)=O

form

powder or solid

mol wt

3,000-15,000

technique(s)

cell culture | mammalian: suitable

color

white to off-white

storage temp.

−20°C

Quality Level

200

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Analysis Note

Molecular weight based on viscosity. Also assayed by MALLS.

Application

Poly-DL-ornithine hydrobromide has been used to coat coverslips to seed dorsal root ganglion neurons from rats. It has also been used to coat dishes for mouse cortical neuron culture.

Biochem/physiol Actions

Poly-DL-ornithine is a basic polypeptide that provides an ideal condition for the growth of neurons in culture. It inhibits the growth of bacteria.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000511907
0000511907
0000471313
0000471311
0000471311

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Wafa Kammouni et al.
Journal of neurovirology, 23(3), 358-368 (2016-12-21)
Our previous work in a mouse model of experimental rabies showed neuronal process (dendrites and axons) degeneration in association with severe clinical disease. Cultured adult rodent dorsal root ganglion (DRG) neurons infected with the challenge virus standard-11 (CVS) strain of
Coatings of Different Carbon Nanotubes on Platinum Electrodes for Neuronal Devices: Preparation, Cytocompatibility and Interaction with Spiral Ganglion Cells
Niklas B
PLoS ONE (2016)
Susan Noell et al.
The European journal of neuroscience, 26(8), 2109-2118 (2007-10-12)
Agrin is a heparan sulfate proteoglycan of the extracellular matrix and is known for organizing the postsynaptic differentiation of the neuromuscular junction. Increasing evidence also suggests roles for agrin in the developing CNS, including the formation and maintenance of the
Neuronal migration on laminin in vitro.
Liang S, Crutcher KA.
Brain Research. Brain Research Reviews, 66, 127-132 (1992)
S H Parson et al.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 4(1), 99-106 (1995-03-01)
We have measured the effects of cytosine-beta-D-arabinofuranoside (AraC) on cell survival and neurite outgrowth in cultures of dissociated 4-6 day embryonic chick neural tube cells. High concentrations of AraC (greater than 100 microM) reduced neuronal cell survival and neurite outgrowth
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