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P8638

Poly-DL-ornithine hydrobromide

Name: Poly-<SC>DL</SC>-ornithine hydrobromide
Brand: SIGMA

suitable for cell culture, Mol wt 3,000-15,000

Synonym(s):

DL-Ornithine homopolymer hydrobromide

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About This Item

CAS Number:

82682-33-5

UNSPSC Code:

12352209

PubChem Substance ID:

24898960

NACRES:

NA.26

MDL number:

MFCD00166384

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Properties

Product Name

Poly-DL-ornithine hydrobromide, mol wt 3,000-15,000

form

powder or solid

Quality Level

200

mol wt

3,000-15,000

technique(s)

cell culture | mammalian: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Br.NCCCC(N)C(O)=O

InChI

1S/C5H12N2O2.BrH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H

InChI key

GWRQMKDBBHFVIZ-UHFFFAOYSA-N

Description

Application

Poly-DL-ornithine hydrobromide has been used to coat coverslips to seed dorsal root ganglion neurons from rats. It has also been used to coat dishes for mouse cortical neuron culture.

Biochem/physiol Actions

Poly-DL-ornithine is a basic polypeptide that provides an ideal condition for the growth of neurons in culture. It inhibits the growth of bacteria.

Analysis Note

Molecular weight based on viscosity. Also assayed by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000557443

0000511907

0000471313

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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Neuronal migration on laminin in vitro.

Liang S, Crutcher KA.

Brain Research. Brain Research Reviews, 66, 127-132 (1992)

Cell viability and laminin-induced neurite outgrowth in cultures of embryonic chick neural tube cells: effects of cytosine-B-D-arabinofuranoside.

S H Parson et al.

Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 4(1), 99-106 (1995-03-01)

We have measured the effects of cytosine-beta-D-arabinofuranoside (AraC) on cell survival and neurite outgrowth in cultures of dissociated 4-6 day embryonic chick neural tube cells. High concentrations of AraC (greater than 100 microM) reduced neuronal cell survival and neurite outgrowth

Serine residues at positions 162 and 166 of the rabies virus phosphoprotein are critical for the induction of oxidative stress in rabies virus infection.

Wafa Kammouni et al.

Journal of neurovirology, 23(3), 358-368 (2016-12-21)

Our previous work in a mouse model of experimental rabies showed neuronal process (dendrites and axons) degeneration in association with severe clinical disease. Cultured adult rodent dorsal root ganglion (DRG) neurons infected with the challenge virus standard-11 (CVS) strain of

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Global Trade Item Number

SKU	GTIN
P8638-250MG	04061834401582
P8638-25MG	04061832780740
P8638-500MG	04061834401599
P8638-100MG	04061832780726