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P8582

Sigma-Aldrich

Podophyllin from Podophyllum emodii

powder

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Synonym(s):
Podophyllum resin
CAS Number:
9000-55-9
EC Number:
232-546-2
MDL number:
MFCD00131926
UNSPSC Code:
12352204
NACRES:
NA.83

form

powder

color

brown

storage temp.

2-8°C

InChI

1S/2C22H24O9.2C22H22O8/c2*1-27-16-4-10(5-17(28-2)21(16)29-3)18-11-6-14-15(31-9-30-14)7-12(11)20(24)13(8-23)19(18)22(25)26;2*1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h2*4-7,13,18-20,23-24H,8-9H2,1-3H3,(H,25,26);2*4-7,13,18-20,23H,8-9H2,1-3H3

InChI key

KOUZYZCESNTXJO-UHFFFAOYSA-N

General description

Podophyllin is an alcoholic plant extract, obtained from the dried rhizome and roots of Podoplryllui emodi. It is a powder with colors varying from light brown to greenish-yellow and exposure to heat or light turns it darker.

Biochem/physiol Actions

Podophyllin is used to treat condylomata acuminate, a type of venereal warts. It exhibit several biological functions and is mainly used in the treatment of constipation, hepatic disorder and rheumatic arthritis.

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1B

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Condylomata acuminata: two hundred cases treated with podophyllin
Culp OS and Kaplan IW
Annals of Surgery, 120(2), 251-251 (1944)
Simultaneous determination of podophyllotoxin, quercetin and kaempferol in podophyllin by liquid chromatography tandem mass spectrometry
Lin M C, et al.
Journal of food and drug analysis, 16(6), 251-251 (2008)
Podophyllin and its use in the treatment of condylomata acuminata
Sundharam J A, et al.
Indian Journal of Dermatology, Venereology and Leprology, 56(1), 10-10 (1990)
Condylomata acuminata in infants and young children. Topical podophyllin an effective therapy.
Khalifa E Sharquie et al.
Saudi medical journal, 26(3), 502-503 (2005-04-05)
François Aubin et al.
Bulletin de l'Academie nationale de medecine, 191(3), 585-597 (2007-12-13)
Human papillomaviruses (HPV) are found in most human epithelia and some tumors. Most HPV strains associated with cutaneous lesions belong to three types, named alpha, beta and gamma. Although the causal link between genital human papillomavirus infection and cervical neoplasia
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