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P8511

trans-2-Phenylcyclopropylamine hydrochloride

Synonym(s):

Tranylcypromine

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About This Item

Linear Formula:
C6H5C3H4NH2·HCl
CAS Number:
1986-47-6
Molecular Weight:
169.65
NACRES:
NA.77
PubChem Substance ID:
24278187
UNSPSC Code:
12352116
MDL number:
MFCD00063602
Assay:
≥97% (TLC)
Form:
powder
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biological source

synthetic (organic)

assay

≥97% (TLC)

form

powder

mp

162-169 °C (lit.)

solubility

ethanol: 50 mg/mL, clear to slightly hazy

storage temp.

2-8°C

SMILES string

Cl.N[C@@H]1C[C@H]1c2ccccc2

InChI

1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1

InChI key

ZPEFMSTTZXJOTM-OULXEKPRSA-N

Gene Information

human ... MAOA(4128), MAOB(4129)

Biochem/physiol Actions

Non-selective MAO-A/B inhibitor.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ2714
MKCV1005
MKCV1004
MKBW0574V
MKBR4169V

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Articles

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

血清素合成及代谢

血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。

Navneet Goyal et al.
Journal of cancer metastasis and treatment, 7 (2021-11-02)
In this study, our goal was to study the inhibition of nicotine metabolism by P450 2A6, as a means for reduction in tobacco use and consequently the prevention of smoking-related cancers. Nicotine, a phytochemical, is an addictive stimulant, responsible for
Navneet Goyal et al.
Chemical research in toxicology, 36(12), 1973-1979 (2023-11-14)
As a potential means for smoking cessation and consequently prevention of smoking-related diseases and mortality, in this study, our goal was to investigate the inhibition of nicotine metabolism by P450 2A6. Smoking is the main cause of many diseases and
Erin A Clark et al.
Cell reports, 27(12), 3522-3532 (2019-06-20)
KDM1A-mediated H3K4 demethylation is a well-established mechanism underlying transcriptional gene repression, but its role in gene activation is less clear. Here, we report a critical function and mechanism of action of KDM1A in glucocorticoid receptor (GR)-mediated gene transcription. Biochemical purification of
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Global Trade Item Number

SKUGTIN
P8511-250MG04061834401506
P8511-5G04061832948522
P8511-1G04061826692332