Key Documents

View All Documentation

P8399

Psoralen

Name: Psoralen
Brand: SIGMA

≥99% (HPLC), DNA photo-crosslinker, powder

Synonym(s):

6,7-Furanocoumarin, 7H-Furo[3,2-g]benzopyran-7-one, Ficusin, Furo[3,2-g]coumarin

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₁H₆O₃

CAS Number:

66-97-7

Molecular Weight:

186.16

NACRES:

NA.77

PubChem Substance ID:

24898918

UNSPSC Code:

12352200

EC Number:

200-639-7

MDL number:

MFCD00010520

Beilstein/REAXYS Number:

152784

Assay:

≥99% (HPLC)

Form:

powder

Quality level:

200

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Psoralen, ≥99% (HPLC)

Quality Level

200

assay

≥99% (HPLC)

form

powder

fluorescence

λ_ex 335 nm; λ_em 460 nm (pH 7.0)

storage temp.

2-8°C

SMILES string

O=C1Oc2cc3occc3cc2C=C1

InChI

1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H

InChI key

ZCCUUQDIBDJBTK-UHFFFAOYSA-N

Description

Application

Psoralen has been used:

as a crosslinker for dsRNA for in- situ hybridization studies
in testing melanin dispersal effects in fish scale melanophores
to test its stimulatory effects in osteoblast a cell proliferation assay
as a reference standard in high-performance liquid chromatography (HPLC)

Photochemical reagent for the investigation of nucleic acid structure and function.

Biochem/physiol Actions

Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Still not finding the right product?

Explore all of our products under Psoralen

pictograms

GHS07

signalword

Warning

hcodes

H302,H317

pcodes

P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000410710

0000196468

0000340749

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

View All Articles

Psoralen and ultraviolet a light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packing

Van Aelst B, et al.

The Journal of Biological Chemistry, 291(47), 24364-24376 (2016)

Psoralen stimulates osteoblast proliferation through the activation of nuclear factor-kappaB-mitogen-activated protein kinase signaling

Li F, et al.

Experimental and Therapeutic Medicine, 14(3), 2385-2391 (2017)

Psoralen and isopsoralen ameliorate sex hormone deficiency-induced osteoporosis in female and male mice

Yuan X, et al.

BioMed Research International, 2016 (2016)

View All Related Papers

Global Trade Item Number

SKU	GTIN
P8399-25MG	04061833024379
P8399-100MG	04061834401414
P8399-10MG	04061834401421