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P8013

Sigma-Aldrich

Pargyline hydrochloride

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Synonym(s):
N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride
Linear Formula:
C6H5CH2N(CH3)CH2C≡CH·HCl
CAS Number:
306-07-0
Molecular Weight:
195.69
Beilstein:
3699487
EC Number:
206-175-1
MDL number:
MFCD00012492
UNSPSC Code:
12352200
PubChem Substance ID:
24278153
NACRES:
NA.77

biological source

synthetic

Quality Level

200

Assay

98% (TLC)

form

powder or crystals

mp

160-163 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl[H].CN(CC#C)Cc1ccccc1

InChI

1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H

InChI key

BCXCABRDBBWWGY-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128) , MAOB(4129)

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Application

Pargyline hydrochloride has been used:
  • as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training
  • to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats,
  • to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum

Biochem/physiol Actions

Pargyline hydrochloride acts as a histone demethylase inhibitor. It has antihypertensive action.
Selective MAO-B inhibitor.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Debapriya Saha et al.
Epigenomes, 4(4) (2021-04-09)
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Ifrim DC, et al.
Clinical and Vaccine Immunology : CVI, 21(4), 534-545 (2014)
Biochemical Pathway for the Formation of Abnormal Sclerotia of Sclerotinia sclerotiorum
Huang HC and Yeung JM
Plant Pathology, 11(1), 2-2 (2002)
Erica P Cai et al.
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