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P7877

Sigma-Aldrich

6-Phosphogluconic acid trisodium salt

≥97% (enzymatic)

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Synonym(s):
D-Gluconate 6-phosphate trisodium salt
Empirical Formula (Hill Notation):
C6H10Na3O10P
CAS Number:
53411-70-4
Molecular Weight:
342.08
Beilstein:
3814212
EC Number:
258-543-6
MDL number:
MFCD00083681
UNSPSC Code:
12352201
PubChem Substance ID:
24898882
NACRES:
NA.25

biological source

synthetic (organic)

Quality Level

200

Assay

≥97% (enzymatic)

form

powder

impurities

<0.05 mol % glucose-6-phosphate

color

light yellow

solubility

water: 50 mg/mL, clear, colorless

cation traces

Na: 18.8-21.5% (dry basis)

application(s)

agriculture

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

1S/C6H13O10P.3Na/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12;;;/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15);;;/q;3*+1/p-3/t2-,3-,4+,5-;;;/m1.../s1

InChI key

CBQSOSFCUWVWAQ-CXKLNRRHSA-K

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Application

6-Phosphogluconic acid has been used in a study to assess a spectrophotometric method for the determination of creative phosphokinase and myokinase. It has also been used in a study to investigate the reversible enzymatic sythesis of diphosphopyridine nucleotide and inorganic pyrophosphate.

Biochem/physiol Actions

Phosphogluconic acid is an intermediate in the pentose phosphate pathway.

Preparation Note

Prepared by a modification of the procedure of Seegmiller, J.E., et al., J. Biol. Chem., 192, 175 (1951).

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reversible enzymatic sythesis of diphosphopyridine nucleotide and inorganic pyrophosphate
Kornberg, A.
The Journal of Biological Chemistry, 182, 779-793 (1950)
A spectrophotometric method for the determination of creatine phosphokinase and myokinase.
I T OLIVER
The Biochemical journal, 61(1), 116-122 (1955-09-01)
Yasaman Barekatain et al.
Communications biology, 3(1), 328-328 (2020-06-27)
Magnetic resonance (MR) spectroscopy has potential to non-invasively detect metabolites of diagnostic significance for precision oncology. Yet, many metabolites have similar chemical shifts, yielding highly convoluted 1H spectra of intact biological material and limiting diagnostic utility. Here, we show that
Ruilong Liu et al.
Nature communications, 10(1), 991-991 (2019-03-03)
6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles

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