P7123
Protein Kinase Cν (PKCν) Active human
recombinant, expressed in E. coli, ≥75% (SDS-PAGE), buffered aqueous glycerol solution
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Synonym(s):
PKD3, Protein Kinase C nu
Recommended Products
recombinant
expressed in E. coli
Quality Level
Assay
≥75% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
protein apparent mol wt ~142 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PRKD3(23683)
Application
Kinase activity is measured as the molar amount of phosphate incorporated into the CREBtide substrate peptide (KRREILSRRPSYR) per minute per mg protein at 30 °C using a final concentration of 50 μM [32P] ATP.
Biochem/physiol Actions
PKCν, also known as PKD3, is a member of the protein kinase C (PKC) family of serine/threonine kinases that play critical roles in the regulation of cellular differentiation and proliferation in many cell types. PKCν is an important physiologic target of the B-cell receptor (BCR) and exhibits activation upon BCR engagement.
Physical form
Solution of 5 μg in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, and 30% glycerol
Regulatory Information
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Certificates of Analysis (COA)
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