Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

P6744

Sigma-Aldrich

Picric acid solution

1.3% in H2O (saturated)

Synonym(s):

2,4,6-Trinitrophenol

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
(O2N)3C6H2OH
CAS Number:
88-89-1
Molecular Weight:
229.10
Beilstein:
423400
MDL number:
MFCD00007102
UNSPSC Code:
12171500
PubChem Substance ID:
24898790
NACRES:
NA.47

form

liquid

Quality Level

200

concentration

1.3% in H2O (saturated)

color

yellow to very dark yellow

density

1.080 g/cm3

application(s)

hematology
histology

storage temp.

room temp

SMILES string

Oc1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O

InChI

1S/C6H3N3O7/c10-6-4(8(13)14)1-3(7(11)12)2-5(6)9(15)16/h1-2,10H

InChI key

OXNIZHLAWKMVMX-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Picric acid is a polynitrated aromatic acid. It dissolves in water to form a solution with low pH (pH 2.0). It interacts with basic groups of proteins, forms salts and coagulates them. Fixation with picric acid gives a bright stain, but there might be a loss of nucleic acids due to the low pH of the solution.
Picric acid is anionic and has a low molecular weight.

Application

Picric acid is commonly used as a fixative and staining reagent in forensic and histological applications. It is a general cytoplasmic stain, connective tissue fiber stain, and a fixative for tissues.
  • It is a component of picrosirius red which is used to stain collagen.
  • Bouin’s fluid which also comprises picric acid is a fixative for nuclei and connective tissue.
  • It can be used as a colorimetric reagent in creatinine determination assay.

Supplementary Hazards

EUH001

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Andre Picot, P. Grenouillet
Safety in the Chemistry and Biochemistry Laboratory (1994)
Histological and histochemical methods: Theory and practice (5th ed.)
JA Kiernan
Histological and Histochemical Methods: Theory and Practice (2015)
Regulator of G-Protein Signaling-5 Is a Marker of Hepatic Stellate Cells and Expression Mediates Response to Liver Injury
Arya Bahrami
PLoS ONE (2014)
Xin Is a Marker of Skeletal Muscle Damage Severity in Myopathies
The American Journal of Pathology, 183 (2013)
Reexploring picrosirius red: A review
Gopinathan, et al.
Indian Journal of Pathology & Microbiology, 7(2) (2020)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service