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Safety Information

P6004

Sigma-Aldrich

Prednisolone

≥99% (HPLC), powder, glucocorticoid

Synonym(s):

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione

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100 μG
CN¥4,985.59

CN¥4,985.59

Estimated to ship onApril 15, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZMS1017
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100 μG
CN¥4,985.59

About This Item

Empirical Formula (Hill Notation):
C21H28O5
CAS Number:
50-24-8
Molecular Weight:
360.44
Beilstein:
1354103
EC Number:
200-021-7
MDL number:
MFCD00003649
UNSPSC Code:
12352200
PubChem Substance ID:
24898725
NACRES:
NA.77

CN¥4,985.59

Estimated to ship onApril 15, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZMS1017
Request a Bulk Order

Product Name

Prednisolone, ≥99%

biological source

synthetic (organic)

sterility

non-sterile

Assay

≥99%

form

powder

mp

240 °C (dec.) (lit.)

solubility

chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow

originator

Johnson & Johnson

shipped in

ambient

storage temp.

room temp

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antibody form

purified immunoglobulin

antibody form

purified antibody

antibody form

ascites fluid

antibody form

purified antibody

biological source

mouse

biological source

mouse

biological source

mouse

biological source

rat

shipped in

ambient

shipped in

ambient

shipped in

wet ice

shipped in

wet ice

technique(s)

ChIP: suitable, dot blot: suitable, immunoprecipitation (IP): suitable, affinity binding assay: suitable, immunocytochemistry: suitable

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

ChIP: suitable (ChIP-seq), ELISA: suitable, immunocytochemistry: suitable, western blot: suitable

isotype

IgG2aκ

isotype

IgG1

isotype

IgG1

isotype

IgG2bκ

General description

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD),[1] gout arthritis[2] and chronic obstructive pulmonary disease (COPD) exacerbations.[3]

Application

Prednisolone has been used for the Δ1-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.[4]

Biochem/physiol Actions

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Analysis Note

Actual content given on label

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360FD

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000418804
    0000418816
    0000418805
    0000418818
    0000415780

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    Continuous non-aerated Delta 1-dehydrogenation of hydrocortisone by PAAH-bead entrapped Arthrobacter simplex
    Silbiger E and Freeman A
    Applied Microbiology and Biotechnology, 29(5), 413-418 (1988)
    H Schäcke et al.
    British journal of pharmacology, 158(4), 1088-1103 (2009-05-09)
    Glucocorticoids are highly effective in the therapy of inflammatory diseases. Their value, however, is limited by side effects. The discovery of the molecular mechanisms of the glucocorticoid receptor and the recognition that activation and repression of gene expression could be
    Oral or IV Prednisolone in the Treatment of COPD Exacerbations
    de Jong YP, et al.
    Chest, 132(6), 1741-1747 (2007)
    Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle
    Wehling-Henricks M, et al.
    Neuromuscular Disorders, 14(8-9), 483-490 (2004)
    Shin Ebihara et al.
    Arthritis research & therapy, 18(1), 139-139 (2016-06-16)
    Dimethyl fumarate (DMF), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, has been proven effective for the systemic treatment of multiple sclerosis. The aim of this study is to evaluate the anti-inflammatory effects of Nrf2 activators on human renal
    View All Related Papers

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