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Merck
CN

P5648

β-Propiolactone

Grade II, ≥90%

Synonym(s):

Oxetan-2-one, 3-Hydroxypropionic acid lactone, Hydracrylic acid β-lactone

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About This Item

Empirical Formula (Hill Notation):
C3H4O2
CAS Number:
57-57-8
Molecular Weight:
72.06
NACRES:
NA.77
PubChem Substance ID:
24898684
UNSPSC Code:
12352103
EC Number:
200-340-1
MDL number:
MFCD00005169

Key Documents

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InChI key

VEZXCJBBBCKRPI-UHFFFAOYSA-N

InChI

1S/C3H4O2/c4-3-1-2-5-3/h1-2H2

SMILES string

O=C1CCO1

type

Grade II

assay

≥90%

refractive index

n20/D 1.412 (lit.)

bp

162 °C (lit.)

mp

−33 °C (lit.)

density

1.146 g/mL at 25 °C (lit.)

storage temp.

−20°C

Quality Level

200

General description

β-Propiolactone is an alkylating agent which is mainly used in veterinary vaccines. It will not interfere with the antigenicity of vaccine.

Application

β-Propiolactone has been used for Influenza virus deactivation.

Disclaimer

Insoluble polymers may form during storage.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

158.0 °F - closed cup

flash_point_c

70 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCF5742
SLCD4922
SLBT1931
SLBT0025
SLBR8147V

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Drishya Kurup et al.
PLoS pathogens, 17(3), e1009383-e1009383 (2021-03-26)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent coronavirus that has caused a worldwide pandemic. Although human disease is often asymptomatic, some develop severe illnesses such as pneumonia, respiratory failure, and death. There is an urgent need for
Tiago Abreu-Mota et al.
Nature communications, 9(1), 4223-4223 (2018-10-13)
Lassa fever (LF), caused by Lassa virus (LASV), is a viral hemorrhagic fever for which no approved vaccine or potent antiviral treatment is available. LF is a WHO priority disease and, together with rabies, a major health burden in West
Vesla I Kullaya et al.
Viral immunology, 30(8), 576-581 (2017-08-08)
Detection of respiratory syncytial virus (RSV) in blood, including mononuclear leukocytes and organs other than the lung, suggests that RSV disseminates outside the respiratory tract. In this study, the role of platelets in host defense against RSV was explored using
Veterinary Immunology-E book, 262-262 (2013)
The genetic properties of beta-propiolactone.
D J Brusick
Mutation research, 39(3-4), 241-255 (1977-01-01)
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