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Safety Information

P5648

Sigma-Aldrich

β-Propiolactone

Grade II, ≥90%

Synonym(s):

Oxetan-2-one, 3-Hydroxypropionic acid lactone, Hydracrylic acid β-lactone

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About This Item

Empirical Formula (Hill Notation):
C3H4O2
CAS Number:
57-57-8
Molecular Weight:
72.06
EC Number:
200-340-1
MDL number:
MFCD00005169
UNSPSC Code:
12352103
PubChem Substance ID:
24898684
NACRES:
NA.77

type

Grade II

Quality Level

200

Assay

≥90%

refractive index

n20/D 1.412 (lit.)

bp

162 °C (lit.)

mp

−33 °C (lit.)

density

1.146 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

O=C1CCO1

InChI

1S/C3H4O2/c4-3-1-2-5-3/h1-2H2

InChI key

VEZXCJBBBCKRPI-UHFFFAOYSA-N

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General description

β-Propiolactone is an alkylating agent which is mainly used in veterinary vaccines. It will not interfere with the antigenicity of vaccine.

Application

β-Propiolactone has been used for Influenza virus deactivation.

Caution

Insoluble polymers may form during storage.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H315,H319,H330,H350

Hazard Classifications

Acute Tox. 2 Inhalation - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

158.0 °F - closed cup

Flash Point(C)

70 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCF5742
SLCD4922
SLBT1931
SLBT0025
SLBR8147V

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Veterinary Immunology-E book, 262-262 (2013)
Vesla I Kullaya et al.
Viral immunology, 30(8), 576-581 (2017-08-08)
Detection of respiratory syncytial virus (RSV) in blood, including mononuclear leukocytes and organs other than the lung, suggests that RSV disseminates outside the respiratory tract. In this study, the role of platelets in host defense against RSV was explored using
Paul David et al.
PLoS pathogens, 16(3), e1008340-e1008340 (2020-04-01)
Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections. Whether such therapies are efficient during an acute infection remains elusive. To address this, inhibitory receptors were
The genetic properties of beta-propiolactone.
D J Brusick
Mutation research, 39(3-4), 241-255 (1977-01-01)
Saunders Comprehensive Veterinary Dictionary E-Book, 34-34 (2011)
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